en Neurology Neurology Case Series Case Series <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Neuromyelitis optica spectrum disorder (NMOSD) is a neuroinflammatory disorder with a tendency to affect the spinal cord and optic nerves. As NMOSDs have a predilection for women of reproductive age and adopt an aggressive course during pregnancy, appropriate treatment strategies before conception and during pregnancy should be well-considered.<br> <span style="color:#0000ff;"><strong><em>Case Presentation</em></strong><em>:</em></span> In this report, the pregnancy outcome of eight pregnancies following rituximab treatment was assessed, which led to 50% live births with mean birth weight of 2777.50 (SD: 545.92) grams. Two patients had abortions due to doctor&rsquo;s recommendation.&nbsp; One pregnancy led to intrauterine fetal death (IUFD) due to nuchal cord.&nbsp; No spontaneous abortions were encountered. Two patients received rituximab during pregnancy. No major malformations or serious neonatal infections were encountered.<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> Rituximab should be administered by caution in NMOSD patients who want to be pregnant and the probable adverse effects of the drug should be discussed by patients.</span></span> Neuromyelitis Optica Spectrum Disorder, Rituximab, pregnancy 491 494 http://caspjim.com/browse.php?a_code=A-10-646-9&slc_lang=en&sid=1 Maral Seyed Ahadi maral_ahadi@yahoo.com 100319475328460031274 100319475328460031274 No Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ali Sahraian sahraian1350@yahoo.com 100319475328460031275 100319475328460031275 No Multiple Sclerosis Research Center; Neuroscience institute; Tehran University of Medical Sciences; Tehran; Iran Vahid Shaygannejad v.shaygannejad@gmail.com 100319475328460031276 100319475328460031276 No Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Nassim Anjidani anjidani.n@orchidpharmed.com 100319475328460031277 100319475328460031277 No Medical Department, Orchid Pharmed Company, Tehran, Iran Seyed Ehsan Mohammadiani Nejad ehsan_neuro@yahoo.com 100319475328460031278 100319475328460031278 No Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Nahid Beladi Moghadam nbeladi@sbmu.ac.ir 100319475328460031279 100319475328460031279 No Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hormoz Ayromlou ayromlouh@gmail.com 100319475328460031280 100319475328460031280 No Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Iran Gholam Ali Yousefi Pour yousefipour@yahoo.com 100319475328460031281 100319475328460031281 No Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran Sepideh Yazdanbakhsh s_yazdanbakhsh@yahoo.com 100319475328460031282 100319475328460031282 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Mehrdad Jafari mehrdadj82@yahoo.com 100319475328460031283 100319475328460031283 No Imam Khomeini Hospital complex, Tehran University of Medical Sciences, Tehran, Iran Abdorreza Naser Moghadasi abdorrezamoghadasi@gmail.com 100319475328460031284 100319475328460031284 Yes Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran