en Endocrinology Endocrinology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Hypoglycemia is frequently associated with insulin therapy in diabetic patients; it leads to many short and long-term complications and even death if not addressed in time. This study was undertaken to observe the circadian propensity of hypoglycemia and its recovery time based on type 2 diabetes mellitus patients&rsquo; clinical parameters.<br> <span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em> </span>We included type 2 diabetes mellitus (DM) hospitalized patients with the exclusion of patients suffering from critical illness. Data were collected for a period of three months (September to November 2019).<br> <span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em></span> A total of 120 patients were included, comprising 60% males and 40% females. Approximately 55% of patients had hypoglycemic episodes at around 12 am&ndash; 6 am. The most common comorbidity present in these patients was hypertension (43.3%, P=0.931). Anemia (OR-3.765, CI-1.350-5.500, P=0.011), retinopathy (OR 6.066, CI-2.031-8.113, P=0.001), and duration of DM (OR-6.266, CI-2.209-7.774, P=0.001) were significantly associated with the recovery time of hypoglycemia, around 50&plusmn;14.14min in the elderly population of age 60-70. People with BMI 22.5- 27.5 Kg/m²took around 45.66 &plusmn; 19.37 min to recover after treatment.<br> <span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> Time taken to recover from hypoglycemic episodes vary with age and BMI<strong>. </strong>Associated comorbidities such as anemia, retinopathy, and DM duration had a significant bearing on the time taken to recover from hypoglycemia. Recovery time was directly proportional to BMI, a new finding that needs further molecular level evaluation. Circadian propensity of hypoglycemia in these patients have been identified in the early morning hours of the day.</span></span> Anemia, Body mass index, Comorbidity, Diabetes Mellitus, Hypoglycemia, hypoglycemic episode, Insulin, Retinopathy 29 37 http://caspjim.com/browse.php?a_code=A-10-2131-1&slc_lang=en&sid=1 Ravi Kant drkantr2006@gmail.com 100319475328460033288 100319475328460033288 No Department of Medicine, All India Institute of Medical Sciences, Rishikesh, India Poonam Yadav dryadavpoonam257@gmail.com 100319475328460033289 100319475328460033289 Yes Center of Excellence in Nursing Education and Research, All India Institute of Medical Sciences, Rishikesh, India Madhuri Pratti madhupratti273@gmail.com 100319475328460033290 100319475328460033290 No Department of Medicine, All India Institute of Medical Sciences, Rishikesh, India Shruti Barnwal drshruti2006@gmail.com 100319475328460033291 100319475328460033291 No Department of Dermatology, Govt. Doon Medical College, Dehradun, India