en Gastroentrology Gastroentrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> NAFLD is one of the most common liver diseases in the world. HOMA-IR as an indicator of insulin resistance is commonly used in clinical trials in NAFLD patients. The aim of this study was to evaluate the application of HOMA-IR index in the diagnosis of NAFLD.<span style="font-size:9.0pt"></span></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Methods:</span></i></b> This study was performed on 54 patients with NAFLD and 54 non-NAFLD patients that referred to Razi Hospital in Rasht during 2019-2020. FibroScan was used to diagnose NAFLD in the patient group and ultrasound was used to rule it out in the control group. Metabolic and hepatic parameters were measured for each patient. Data were entered into SPSS 22 software and the necessary analyses were performed.<i><span style="font-size:10.0pt"></span></i></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Results:</span></i></b> The mean age of the subjects in the study was 44.01&plusmn;13.12 years and ranged from 18 to 75 years. 72.2% of people affected by NAFLD were men (p <0.001) .The optimal cut-off point for HOMA-IR in NAFLD was 1.65 with a sensitivity of 89.7% and a specificity of 76.9% in men and 1.90 with a sensitivity of 86.7% and a specificity of 82.9% in women. Overall, the optimal cut-off point for HOMA-IR in NAFLD was 1.75 with a sensitivity of 87.0% and a specificity of 81.5%. In addition, the results showed that there was no significant relationship between steatosis and hepatic fibrosis with HOMA-IR index.<b><i><span style="color:blue"></span></i></b></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The results showed that HOMA-IR can be used as a reliable criterion for early detection of NAFLD.</span></span></span></span><span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:#0033cc"></span></span></i></b></span></span></span> NAFLD, HOMA-IR, insulin resistance, FibroScan, BMI. 519 526 http://caspjim.com/browse.php?a_code=A-10-2139-1&slc_lang=en&sid=1 Behrang Motamed behrang.mot@gmail.com 100319475328460037543 100319475328460037543 No Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Mahsa Kohansal Vajargah m.kohansalv@gmail.com 100319475328460037544 100319475328460037544 No Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Saeed Kalantari saeed.kalntri@gmail.com 100319475328460037545 100319475328460037545 No Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, Iran Afshin Shafaghi drafshinshafaghi@gmail.com 100319475328460037546 100319475328460037546 Yes GI Cancer Screening and Prevention Research Center, Guilan University of Medical Sciences, Rasht, Iran