Caspian Journal of Internal Medicine

en Effect of Oral and parenteral routes of vitamin D supplementation on serum 25(OH) vitamin D levels in patients with non-alcoholic fatty liver disease Internal Internal Original Article Original Article Background: Due to the interruption of the EHC pathway in NAFLD patients, we hypothesized that parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with NAFLD. Therefore, this study aimed to compare the efficacy of oral and parenteral routes of vitamin D supplementation on serum 25(OH) vitamin D levels in patients with NAFLD. Methods: In this prospective randomized trial, 66 NAFLD cases with vitamin D deficiency were studied. For 33 cases, oral vitamin D was supplemented, whereas the other 33 patients were given an intramuscular injection of vitamin D. Laboratory tests and liver ultrasound were performed at the beginning and the end of the trial for each subject. Results: Regardless of the drug administration route, at the end of this trial the mean of serum 25-hydroxy vitamin D level increased from 8.74±2.47 to 33.16±17.61 (P=0.00), and the mean±SD for serum triglyceride decreased from 191.46±92.79 to 166.00±68.30 (P=0.02), both were statistically significant. Liver ultrasound reported statistically significant changes in the grade of fatty liver disease (P=0.003). In the comparison between the two groups, serum 25-hydroxy vitamin D level changes were not statistically significant (P=0.788). Conclusion: The intramuscular method of supplementation was not better than the oral route in improving serum 25(OH) vitamin D levels in NAFLD patients. In this study, the impaired EHC and vitamin D absorption inhibitor factors in NAFLD patients did not affect the final result of serum vitamin D levels significantly. Nonalcoholic fatty liver disease, Vitamin D, Routes of administration 23 28 http://caspjim.com/browse.php?a_code=A-10-2144-1&slc_lang=en&sid=1 Arezou Hamzehzadeh Alamdari alamdari.arezou@gmail.com 100319475328460033282 100319475328460033282 Yes Gastroenterology and Liver Diseases Research Center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Samira Ahrabi samira.araqchinahrabi@gmail.com 100319475328460033283 100319475328460033283 No Gastroenterology and Liver Diseases Research center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Manouchehr Khoshbaten mkhoshbaten@yahoo.com 100319475328460033284 100319475328460033284 No Gastroenterology and Liver Diseases Research center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Shahram Roustaei roustaei_shahram@yahoo.com 100319475328460033285 100319475328460033285 No ِِDepartment of Surgery, Tehran University of Medical Sciences, Tehran, Iran Sara Araqchin Ahrabi ahrabisara0@gmail.com 100319475328460033286 100319475328460033286 No Gastroenterology and Liver Diseases Research center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Mohammad Asghari Jafarabadi m.asghari862@gmail.com 100319475328460033287 100319475328460033287 No Department of Statistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran