en Traditional Medicine Short Communication Short Communication <span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:blue">Background</span></span></i></b><i><span style="font-size:10.0pt"><span style="color:blue">:</span></span></i> <span style="font-size:10.0pt">Historical evidence revealed that alcoholic beverages</span> <span style="font-size:10.0pt">have been produced, used and abused thousands of years before the discovery of alcohol by Rhazes for medical purposes. Alcohol-induced liver disease (e.g., steatosis, steatohepatitis, fibrosis and cirrhosis) is one of the most prevalent causes of chronic liver disease all over the world. This study aims to find the early report of this complication in an ancient Persian historical text.</span><span style="font-size:9.0pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:blue">Methods</span></span></i></b><i><span style="font-size:10.0pt"><span style="color:blue">:</span></span></i> <span style="font-size:10.0pt">In this study, the book of <i>Minooye Kherad</i>,</span> <span style="font-size:10.0pt">a Zoroastrian manuscript </span><span style="font-size:10.0pt">on wisdom which was written </span><span style="font-size:10.0pt">in the late Sassanid Empire (224&ndash;637 CE) is reviewed.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:blue">Results</span></span></i></b><i><span style="font-size:10.0pt"><span style="color:blue">:</span></span></i> <span style="font-size:10.0pt">However, the concept of alcohol hepatotoxicity as one of the most important complications of alcoholism is a new terminology, by researching historical documents</span><span style="font-size:10.0pt"> it </span><span style="font-size:10.0pt">can be found that one of the oldest reports of benefits and disadvantages of drinking</span> <span style="font-size:10.0pt">wine focusing on liver complications is</span> <span style="font-size:10.0pt">mentioned in the book of <i>Minooye</i>.</span><i><span style="font-size:10.0pt"></span></i></span></span></span><br> <span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:blue">Conclusion</span></span></i></b><i><span style="font-size:10.0pt"><span style="color:blue">:</span></span></i> <span style="font-size:10.0pt">Description of the liver disease and damage caused by excessive alcohol consumption in this valuable book can be considered as the early report of hepatotoxicity of alcoholic beverages in the medical history.</span><b><i><span style="font-size:10.0pt"><span style="color:#0033cc"></span></span></i></b></span></span></span><br> &nbsp; Alcoholism, history of medicine, liver injury, Persian Medicine, wine 431 435 http://caspjim.com/browse.php?a_code=A-10-2162-1&slc_lang=en&sid=1 Hanan Hamdi hananhamdi095@gmail.com 100319475328460036294 100319475328460036294 No Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Samaneh Soleymani s_soleymani@razi.tums.ac.ir 100319475328460036295 100319475328460036295 No Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Arman Zargaran zargarana@sums.ac.ir 100319475328460036296 100319475328460036296 Yes Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran