en Oncology Oncology Short Communication Short Communication <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Oral mucositis is a troublesome symptom for people who receive radiotherapy and chemotherapy and it is a dose-dependent factor. Atorvastatin is a HMG-CoA reductase inhibitors and various studies have proven its anti-inflammatory effects. The goal of this study was to evaluate atorvastatin 1% mouthwash effects in prevention of radiotherapy-induced mucositis.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> Atorvastatin 1% suspension was prepared for mouthwash in this randomized, double-blind clinical trial. Thirty patients randomly received atorvastatin or placebo mouthwash. They had to gargle 5cc of mouthwash, 3 times per day during radiotherapy. The severity and pain of mucositis was evaluated every week, during their treatment.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> The severity of mucositis between the two study groups was significant every four weeks (p<0.05) and the percentage of patients with more severe mucositis was less in the atorvastatin group. It is found that the pain intensity was lower after 3 and 4 weeks in atorvastatin group.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> These findings indicated that atorvastatin mouthwash showed a significant activity in relieving of radiotherapy-induced oral mucositis and pain.<b><i><span style="color:#0033cc"></span></i></b></span></span></span> Atorvastatin, Mouthwash, Oral mucositis, Radiotherapy 800 804 http://caspjim.com/browse.php?a_code=A-10-1516-3&slc_lang=en&sid=1 Shahram Ala sh204ala@gmail.com 100319475328460039912 100319475328460039912 No Department of clinical pharmacy, Faculty of pharmacy, Mazandaran University of medical science, Sari, Iran Majid Saeedi majsaeedi@gmail.com 100319475328460039913 100319475328460039913 No Department of Pharmaceutical Sciences, Faculty of pharmacy, Mazandaran University of medical science, Sari, Iran Arash Ghasemi dr_arash_ghasemi@yahoo.com 100319475328460039914 100319475328460039914 Yes Department of radiology and radiation oncology, Faculty of medicine, Mazandaran University of medical science, Sari, Iran Melika Namdari Namdarimelika@gmail.com 100319475328460039915 100319475328460039915 No Student Research Committee, Faculty of pharmacy, Mazandaran University of medical science, Sari, Iran Neda Koulaeinejad nd.koulaei@gmail.com 100319475328460039916 100319475328460039916 No Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran