en Health Health Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">Mild head trauma often causes several complications and disabilities including nausea and vomiting in hospitalized people. The aim of the present study was to compare the effectiveness of metoclopramide and ondansetron, and compare it with placebo to control nausea in the patients with mild head trauma admitted to the emergency department.</span><span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="EN">This is a randomized double-blind placebo-controlled clinical trial conducted on the patients with mild head trauma and normal brain CT scans who were admitted to the emergency department within 24 hours after the injury. The subjects were randomly divided into three groups of ondansetron (n= 41), metoclopramide (n= 44), and placebo (n= 39), and the severity of nausea and vomiting was assessed using the visual analogue scale (VAS). </span>&nbsp;<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span lang="EN">A total of 124 patients with mild head trauma were included in the study. The assessment of the VAS scores during the study showed that over time, the patients in all three groups had reduced nausea (p<0.01). On the other hand, the percentage change of the VAS score indicated that metoclopramide and ondansetron had the greatest changes (46.97% and 66.90%, respectively) within 15 and 30 minutes after the injection, respectively.</span><b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">The results of the present study showed that ondansetron and metoclopramide had similar effects on nausea in the patients with mild head trauma. However, metoclopramide was most effective in 15 minutes and ondansetron in 30 minutes after the injection.</span><b><i><span style="color:#0033cc"></span></i></b></span></span></span> Mild head trauma, nausea, vomiting, Ondansetron, Metoclopramide 699 704 http://caspjim.com/browse.php?a_code=A-10-2257-1&slc_lang=en&sid=1 Hamideh Feiz Disfani feyzh@mums.ac.ir 100319475328460039831 100319475328460039831 No Department of Emergency Medicine, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mostafa Kamandi kamandim@mums.ac.ir 100319475328460039832 100319475328460039832 Yes Department of Hematology Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Seyyedeh Bahareh Hoseini bahare.hoseini66@gmail.com 100319475328460039833 100319475328460039833 No Department of Emergency Medicine, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran Narges Shirazi nargesshirazi1380@yahoo.com 100319475328460039834 100319475328460039834 No Department of Emergency Medicine, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Panahi PanahiM@mums.ac.ir 100319475328460039835 100319475328460039835 No Department of Emergency Medicine, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran