en Oncology Oncology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">Vitamin D (Vit-D) is a necessary ingredient for human growth and its deficiency may increase the risk of cancer and its recurrence. The main purpose of this research was to assess the levels of Vit-D in children with recurrence of malignancy and compare it with new cases of malignancy and the control group.</span><span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="EN">The status of 25(OH) Vit-D was determined utilizing the HPLC method in 47 patients with recurrence of malignancy (group A), 50 children with new malignancy (group B) and 49 normal healthy siblings of the two groups as a control (group C).</span> <span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span lang="EN">Vit-D was low (<30 ng/ml) in the 92% of patients with recurrence of malignancy, which was a significant difference compared to groups B (60%) and C (45%). Vit-D insufficiency (10-30 ng/dl) in group A was also higher than the other two groups. The mean levels of Vit-D in patients with recurrence were significantly lower than the new cases and controls. Low Vit-D (<30 ng/ml) in group A in both male and female, and also in all ages (<6 and &ge; 6 years) was higher than groups B and C. Also, low Vit-D in terms of the type of malignancy in group A was higher than group B only in leukemic patients while this was not different for non-leukemic patients in these two groups.</span><b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">Results of this study showed an increased prevalence of low Vit-D in children with recurrence of malignancies. Therefore, it may increase the risk of recurrence of malignancies in children.</span><b><i><span style="color:#0033cc"></span></i></b></span></span></span> Vitamin D, Recurrence, Cancer, Children 735 740 http://caspjim.com/browse.php?a_code=A-10-1348-2&slc_lang=en&sid=1 Nahid Reisi reisi@med.mui.ac.ir 100319475328460039857 100319475328460039857 Yes Department of Pediatric Hematology and Oncology, Faculty of Medicine, Child Growth and Development Research Center and Isfahan Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Azar Mirzaei schpk_63@yahoo.com 100319475328460039858 100319475328460039858 No Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran Alireza Moafi moafi@med.mui.ac.ir 100319475328460039859 100319475328460039859 No Department of Pediatric Hematology and Oncology, Faculty of Medicine, Child Growth and Development Research Center and Isfahan Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Pouran Raeissi raeissi2009@yahoo.com 100319475328460039860 100319475328460039860 No Department of Health Service Management, School of Health Management and Medical Information Science, Iran University of Medical Sciences, Tehran, Iran Maryam Naghdhassani naghdhasani_m@yahoo.com 100319475328460039861 100319475328460039861 No Department of Psychology, Azad University, Najaf Abad Branch, Isfahan, Iran