en Internal Internal Case Series Case Series <p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Background: </em></strong></span>Alveolar echinococcosis (AE) is a chronic, rare and sometimes lethal parasitic infection in humans, caused by the larval stage of the fox tapeworm Echinococcus multilocularis. This study aimed to investigate the clinical aspects and treatment outcomes of patients with alveolar hydatid disease.</span></p> <p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Methods:</em></strong></span> The medical records of patients with alveolar echinococcosis admitted between 1997 and 2012 were reviewed. Diagnosis was confirmed by physical examination, ultrasonography and CT scanning and MRI. Various treatment techniques were used such as complete liver resection in seven (38.89%) patients, biliary bypass in two (11.11%) patients, laparotomy and tumor biopsy in eight (44.44%) patients and long term medical treatment in one (5.56%) patient. After discharge, all patients were followed to determine the effect of treatment, complications, recurrences and survival.</span></p> <p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Results:</em></strong></span> A total of 18 patients with mean age of 46.11±15.14 years (range 23-74 years) were studied. The disease was more prevalent in women than men (78.9% vs 4, 21.1%, P=0.021). Fourteen (77.78%) patients live in Chenaran, a town located in Khorasan, Iran). Death occurred in (22.22%) patients after an average period of 45.70±7.50 months after disease onset. 14 remaining patients survived after a mean follow-up duration of 54.60±29.17 months.</span></p> <p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Conclusion:</em></strong></span> Diagnosis of alveolar echinococcosis should be considered in endemic area. Early diagnosis and treatment is associated with excellent outcome.</span></p> Alveolar echinoccosis, Echinococcus multilocularis, Diagnosis, Treatment 52 56 http://caspjim.com/browse.php?a_code=A-10-128-1&slc_lang=en&sid=1 Ghodratollah Maddah MaddahGh@mums.ac.ir 10031947532846004688 10031947532846004688 Yes Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Abbas Abdollahi AbdollahiA@mums.ac.ir 10031947532846004689 10031947532846004689 No Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Reza Sharifi Nooghabi SharifiR881@mums.ac.ir 10031947532846004690 10031947532846004690 No Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Alireza Tavassoli TavassoliA@mums.ac.ir 10031947532846004691 10031947532846004691 No Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Taghi Rajabi Mashhadi RajabiMT@mums.ac.ir 10031947532846004692 10031947532846004692 No Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Azadeh Jabbari Nooghabi JabbariA891@mums.ac.ir 10031947532846004693 10031947532846004693 No Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mehdi Jabbari Nooghabi JabbariNM@yahoo.com 10031947532846004694 10031947532846004694 No a: Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. b: Department of Statistics, Faculty of Mathematical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.