en pharmacology pharmacology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-GB">It is pertinent to objectively assess the severity of diabetic gastroparesis and tailor treatment accordingly. The current study was planned to document gastroparesis by gastric emptying scintigraphy (GES) objectively and see the effect of medications and diet control on clinical and GES after four weeks</span>.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="EN-GB">A prospective, open-label randomized trial was conducted in the Department of Internal Medicine at a tertiary care teaching hospital over twelve months.</span><span lang="EN-GB"> Type 2 diabetic patients aged 18-65 years diagnosed with a case of delayed gastric emptying by gastric scintigraphy were included. All baseline GSCI was recorded, and then they were allotted to 3 groups &ndash; Group-1 (Levosulpiride 25mg once daily), group-2 (Cinitapride 1mg thrice daily), and Group-3 (Waitlisted control) by block randomization and followed-up weekly till four weeks. After four weeks duration, if not improved clinically, then Group-3 on diet and diabetic control only, were randomized into Levosulpiride 25mg once daily (Group 1), and Cinitapride 1mg Thrice daily (Group 2) for the next four weeks</span>.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span lang="EN-GB">Forty confirmed cases with diabetic gastroparesis documented by Gastroparesis Symptom Cardinal Index (GCSI) scoring and later by Scintigraphy (GES) were included in this study. However, there was no statistically significant difference between the Levosulpiride and Cinitapride groups when all symptoms were taken into account. Levosulpiride was significantly more effective than Cinitapride in improving individual symptoms like nausea, vomiting, stomach fullness, and early satiety</span>.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-GB">Levosulpiride is better than Cinitapride in improving the symptoms of diabetic gastroparesis but no significant effect on gastric scintigraphy</span>.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; Cinitapride, Diabetes Mellitus, Gastroparesis, Gastric scintigraphy, Gastric Emptying, Levosulpiride. 618 627 http://caspjim.com/browse.php?a_code=A-10-2131-3&slc_lang=en&sid=1 Ravi Kant drkantr2006@gmail.com 100319475328460044860 100319475328460044860 No All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India Madhuri Pratti madhuaiimsrishikesh@gmail.com 100319475328460044861 100319475328460044861 No Department of Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India Meenakshi Khapre drmeenakxi5@yahoo.com 100319475328460044862 100319475328460044862 No All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India Poonam Yadav drpoonam457@gmail.com 100319475328460044863 100319475328460044863 Yes All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India Vandana Dhingra modisbanu@yahoo.com 100319475328460044864 100319475328460044864 No Department of Nuclear Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India