en Reumatology Reumatology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span style="background:white">Behcet&rsquo;s disease is a </span>chronic<span style="background:white">&nbsp;fatal illness with a&nbsp;</span>relapsing remitting<span style="background:white">&nbsp;nature and significant organ-threatening morbidity and mortality. The aim of t</span>his research was to examine studies which were conducted on investigation of prevalence of quality of life among patients with <span style="background:white">Behcet&rsquo;s disease</span>.<span style="font-size:9.0pt"></span></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Methods:</span></i></b> A total of 13 articles were extracted from four main databases including PubMed, EMBASE, Scopus, and Web of Science from the onset of 2000 to January 2021.&nbsp;All studies published in English with the purpose of examining quality of life (QOL) among patients with BD or investigating its main determinants were included.<i><span style="font-size:10.0pt"></span></i></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Results:</span></i></b> Totally, 1137 BD patients participated in 13 studies. Based on random effect analysis, the total score of physical health-related QOL was 46.7 (95% CI=41.26 to 52.13) and the total score of mental health-related QOL was 49.01 (95% CI=43.83 to 54.18) representing a moderate level of QOL among BD patients. Furthermore, weighted effect size analyses showed a significant correlation between QOL and variables such as patients&rsquo; age, gender, disease duration and depression (pvalue: 0.00).<b><i><span style="color:blue"></span></i></b></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> As the symptoms of BD worsen over time, patients confront with more severe body pain, mobility restrictions, and difficulties in chewing, eating, speaking and swallowing which negatively affect social interactions of patients and reduce their QOL. Furthermore, depression was proved to act as a deteriorating factor for HRQOL among BD patients. Thus, patients need to be psychologically supported by a specialized team and be informed during the course of treatment to gain useful information about the disease, treatment approaches and coping strategies.</span></span></span></span><span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:#0033cc"></span></span></i></b></span></span></span> Keywords: Global, health-related quality of life, Behcet’s disease, systematic review. 447 457 http://caspjim.com/browse.php?a_code=A-10-2349-1&slc_lang=en&sid=1 Maryam Masoumi m.masoumiy@gmail.com 100319475328460037483 0654-0654-6546-6546 No Clinical Research and Development Center, Qom University of Medical Sciences, Qom, Iran Alireza Sharifi Habiball.al.sh@gmail.com 100319475328460037484 4987-4987-9579-1654 No Clinical Research and Development Center, Qom University of Medical Sciences, Qom, Iran Sepideh Rezaei Sepiderezaei123456@gmail.com 100319475328460037485 4165-6546-3546-6549 No School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran Sima Rafiei simaraoofi@gmail.com 100319475328460037486 100319475328460037486 No Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran Hossein Hosseinifard hosseinefard@gmail.com 100319475328460037487 6546-6168-1654-6516 No Research Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Saghar Khani sagharkhani1865@gmail.com 100319475328460037488 1549-1651-3249-6548 No School of Medicine, Iran University of Medical Sciences, Tehran, Iran Maryam Doustmehraban maryam.doustmehraban@yahoo.com 100319475328460037489 100319475328460037489 No Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran Mona Rajabi rajabimona98@yahoo.com 100319475328460037490 100319475328460037490 No Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran Zahra Beiramy Chomalou zahrabeiramy1996@gmail.com 100319475328460037491 100319475328460037491 No Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran Parisa Soori soori.parisa@yahoo.com 100319475328460037492 100319475328460037492 No Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran Akbar Javan Biparva akbarjavan4@gmail.com 100319475328460037493 100319475328460037493 No Student Research Committee, School of Health Management and Medical Informatics, Iranian Center of Excellence in Health Management, Tabriz University of Medical Sciences, Tabriz, Iran Afsaneh Dehnad afsanehdehnad@gmail.com 100319475328460037494 100319475328460037494 No School of Health Management and Information Sciences, Center for Educational Research in Medical Sciences (CERMS), Iran University of Medical Sciences, Tehran, Iran Fatemeh Pashazadeh kan negarpashazade9@gmail.com 100319475328460037495 100319475328460037495 No Student Research Committee, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran Ahmad Ghashghaee ahmad.ghashghaee1996@gmail.com 100319475328460037496 100319475328460037496 Yes Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran