Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1401
6
1
gregorian
2022
9
1
13
4
online
1
fulltext
en
Determination of serum alkaline phosphatase reference in healthy children aged 1-18 years
Pediatrics
Pediatrics
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> The growth and development of children affect biochemical variables. This population-based study was designed to evaluate the reference interval for alkaline phosphatase (ALP) routinely measured in the clinical laboratory.<span style="font-size:9.0pt"></span></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> For this examination, 873 cases were selected among the healthy children and adolescents aged 1-18 years who referred to the endocrinology clinic of Amirkola Children's Hospital for growth evaluation. After overnight fasting, early morning blood samples were obtained to measure the ALP level and other biochemical parameters using an automatic biochemical analyzer. Subjects were categorized by age, sex, and body mass index (BMI) values. The age groups were categorized as follows: 1-4 years, 5-8 years, 9-13 years, and 14-18 years.</span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> There was a significant difference among the age and sex <span lang="EN">categories</span>; on the contrary, there was no meaningful variation between the two groups categorized by BMI. The reference range for ALP was 474.14-517.71 U/L for children aged 1-4 years, 273.47-871.44 U/L for 5-8 years, 215.04-893.69 U/L for 9-13 years, and 228.9-739.22 U/L for 14-18 years. Also, significant positive correlation was found between ALP with length (P=0.000, r=0.134), weight (=0.04, r=0.073), phosphorus (P) (P=0.001, r=0.122), and alanine aminotransferase (SGPT) (P=0.000, r=0.142) respectively.<b><i><span style="color:blue"></span></i></b></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> This project's data established a reference interval for ALP in healthy children and adolescents, which will prepare a basis for diagnosis and monitoring liver- or bone-related disorders.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br>
Children, Alkaline phosphatase, Reference interval, Biochemistry, Liver function
749
756
http://caspjim.com/browse.php?a_code=A-10-1423-3&slc_lang=en&sid=1
Mehdi
Gholami Bahnemiri
Mgholami.b@gmail.com
100319475328460039872
100319475328460039872
No
Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Shivasadat
Mirabedini
shiva.mirabedini@live.com
100319475328460039873
100319475328460039873
No
Department of Clinical Biochemistry and Medical Genetics, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of MedicalSciences, Sari, Iran,
Parisa
Mohammadi
pmohamadi807@gmail.com
100319475328460039874
100319475328460039874
No
, Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Haniyeh
Barmaki
Halehbarmaki1982@gmail.com
100319475328460039875
100319475328460039875
No
Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Iran
Zohreh
Qaffaripour
zhr.qaffaripour2020@gmail.com
100319475328460039876
100319475328460039876
No
Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Masomeh
Rezapour
masomeh.rezapour@yahoo.com
100319475328460039877
100319475328460039877
No
Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran.
Morteza
Alijanpour
m.alijanpour@yahoo.com
100319475328460039878
100319475328460039878
Yes
Non-Communicable Pediatric Diseasees Research Center, Health Research Institute, Babol, Iran