en Neurology Neurology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Optic neuritis (ON) is one of the main neuro-ophthalmic presentations of multiple sclerosis (MS), and it causes optic nerve atrophy and axonal loss. However, so far, there is no effective treatment to improve long-term outcomes.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> In a double-blind placebo-controlled randomized clinical trial, 50 patients with MS-related ON were allocated into two arms (24 in the control group and 26 in the intervention group) receiving either 25000IU retinyl palmitate or an identical placebo for six months. Visual evoked potential (VEP), visual acuity, and the retinal nerve fiber layer (RNFL) thickness were evaluated and compared before and after the treatment.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> RNFL thickness reduction in the affected eyes at sixth month compared to the baseline were 14.81 and 19.46 &mu;m, in the intervention and control groups, respectively (P=0.017). However, VitA therapy did not affect visual acuity and VEP.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Vitamin A supplementation in the patients with acute ON in MS could lessen optic nerve axonal loss.<span style="font-size:10.0pt"></span></span></span></span> Multiple Sclerosis, Optic Neuritis, Vitamin A, Axonal damage 23 30 http://caspjim.com/browse.php?a_code=A-10-646-11&slc_lang=en&sid=1 Shiva Rahimi-Dehgolan shivarahimi1366@yahoo.com 100319475328460040779 100319475328460040779 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical sciences, Tehran, Iran Maryam Masoudi maryam.masoudi9@gmail.com 100319475328460040780 100319475328460040780 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical sciences, Tehran, Iran Shahram Rahimi-Dehgolan naser.moghadasi@yahoo.com 100319475328460040781 100319475328460040781 No Physical Medicine and Rehabilitation Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Amir Reza Azimi amirreza_azimi@yahoo.com 100319475328460040782 100319475328460040782 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical sciences, Tehran, Iran Mohammad Ali Sahraian sahraian1350@yahoo.com 100319475328460040783 100319475328460040783 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical sciences, Tehran, Iran Seyed Mohammad Baghbanian mohammadbaghbanian@gmail.com 100319475328460040784 100319475328460040784 No Department of Neurology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Abdorreza Naser Moghadasi abdorrezamoghadasi@gmail.com 100319475328460040785 100319475328460040785 Yes Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical sciences, Tehran, Iran