Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1401
12
1
gregorian
2023
3
1
14
2
online
1
fulltext
en
Langerhans cell histiocytosis presented as bilateral otitis media with effusion, a rare case report
Oncology
Oncology
case report
case report
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Langerhans cell histiocytosis (LCH) or histiocytosis X is considered as a rare disease that may have effect on multiple organs. The initial presentation of LCH is varied. The signs and symptoms of otologic histiocytosis can be the same as the acute or chronic infectious ear diseases. Definitive diagnosis of LCH is confirmed by biopsy and immunohistochemically staining of S-100 protein and CD1a antigen. Chemotherapy is the main mode of treatment.</span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Case presentation:</span></i></b> In this report, we explained the clinical manifestation, diagnosis and treatment of a case of 15 month-old girl with diagnosed of LCH that initially presented with otitis media with effusion (OME).</span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Conclusion: </span></i></b>LCH is a rare disease that presented with variable sign and symptoms and have an effect on multiple organs. LCH should be regarded in cases with recurrent ear infection without response to medical treatments. Moreover, biopsy with IHC is the gold standard of diagnosis and chemotherapy is the main form of treatment.<span style="font-size:10.0pt"></span></span></span></span><br>
Langerhans cell histiocytosis, histiocytosis X, otitis media with effusion, children
401
405
http://caspjim.com/browse.php?a_code=A-10-2037-3&slc_lang=en&sid=1
Soheil
Motamed
smotamed2009@gmail.com
100319475328460042528
100319475328460042528
No
Department of Otorhinolaryngology, Afzalipour faculty of medicine, Kerman University of Medical Sciences, Kerman, Iran/ Student research committee, Kerman University of Medical Sciences, Kerman, Iran
Maryam
Amizadeh
amizade.m@yahoo.com
100319475328460042529
100319475328460042529
Yes
Department of Otorhinolaryngology, Afzalipour faculty of medicine, Kerman University of Medical Sciences, Kerman, Iran
Shahriar
Dabiri
dabiri12@gmail.com
100319475328460042530
100319475328460042530
No
Department of Pathology, Afzalipour faculty of medicine, Kerman University of Medical Sciences, Kerman, Iran