en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span> </i></b>Iron overload is connected with an&nbsp;expanded&nbsp;prevalence of thalassemia due to heart impairment. This&nbsp;considers&nbsp;pointing&nbsp;to&nbsp;survey&nbsp;changes in thalassemia&#39;s aortic elasticity due to iron deposition in the heart and liver of children.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This case-control study was performed on 80 healthy and 160 thalassemia patients. The subjects gathered from educational pediatric hospital of Ali Asghar in Zahedan, Iran, from 2019 to 2021. Echocardiography parameters were measured. Ferritin, lipids profile, cardiac and liver MRI T2 * measured in patients only. Aortic elasticity parameters were aortic strain, aortic stiffness &beta; index, aortic distensibility and pressure strain elastic modulus. Data analyzed by SPSS,p<&thinsp;0.05 was considered as significant.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Diastolic blood pressure (p<0.001), aortic diameter in diastole (p<0.001), aortic diameter in systole (p<0.001), ferritin (p<0.001), aortic strain (p<0.001), aortic distensibility(p<0.001), pressure strain elastic modulus (p<0.001) and aortic stiffness &beta; index (p<0.001) were changed significantly in thalassemia patients compared to controls. From these variables, AoD, AoS, ferritin, AS and AD increased in thalassemia.&nbsp; Ferritin was higher in thalassemia patients with abnormal heart iron deposition (2131.89&plusmn;1992.74 v.s 4887.66&plusmn;3122.59 ng/ml). Considering the level of liver iron deposition, ferritin did not change in patients.&nbsp; Our highlighted variables did not change in patients based on the groups of ferritin.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b> Concluded that AoD, AoS, ferritin, AS and AD increased in thalassemia patients.&nbsp; Ferritin increased in thalassemia with abnormal iron overload in the heart but did not change in the liver. Recommended MRI T2* to evaluate dynamic functions of liver and heart in thalassemia patients.</span></span></span> Aortic elasticity, thalassemia, iron deposition 460 469 http://caspjim.com/browse.php?a_code=A-10-747-5&slc_lang=en&sid=1 Noor Mohammad Noori dr_noori_cardio@yahoo.com 100319475328460042994 100319475328460042994 No Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases , Zahedan University of Medical Science's, Zahedan, Iran Alireza Teimouri alirezateimouri260@gmail.com 100319475328460042995 100319475328460042995 Yes Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, School of Medicine, Zahedan Univ Med Sci, Zahedan 9816743111, Iran