Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1402
2
1
gregorian
2023
5
1
14
3
online
1
fulltext
en
Serologic evaluation of cytomegalovirus (CMV),
Toxoplasma gondii and Brucella in schizophrenia patients
psychiatry
psychiatry
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b><b> </b>Infectious agents are considered as a possible cause of schizophrenia. The aim of this study was to evaluate the serum levels of cytomegalovirus (CMV), Toxoplasma gondii and Brucella antibodies in schizophrenia patients compared with the control group.<span style="font-size:9.0pt"></span></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This cross-sectional study was performed on 75 patients with schizophrenia who were clinically diagnosed with schizophrenia using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) by two independent psychiatrists. As the controls, 75 sex and age-matched individuals were selected from orthopedic and surgical wards, who were admitted because of trauma. Anti-Toxoplasma gondii IgG antibody was detected by Abbott's company diagnostic kit. To detect anti-Brucella IgG antibodies, the enzyme-linked immunosorbent assay (ELISA) test with Vircell diagnostic kit was used. Quantitative luminescence (CLIA) method using Abbott diagnostic kit was also used to detect anti-cytomegalovirus IgG antibody (CMV IgG avidity)<span lang="EN">. </span></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> There was not any clinically significant differences in the mean value of Toxoplasma, CMV and Brucella IgG antibodies between schizophrenia and control group. However, considering cut-off point for these tests and further analysis with non-parametric tests showed clinically significant difference between two groups at cut-off point 1.1 for anti-Brucella IgG antibody which indicated more positive samples in schizophrenia group (24 out of 75) than control group (12 out of 75) with a p-value less than 0.05 (0.046)<span lang="EN">.</span><b><i><span style="color:blue"></span></i></b></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b> The results of the present study showed no association between toxoplasmosis infection and CMV and schizophrenia. However, there might be a positive correlation between anti-Brucella IgG antibody and schizophrenia.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br>
Schizophrenia, Serology, Cytomegalovirus, Brucellosis, Toxoplasmosis
560
566
http://caspjim.com/browse.php?a_code=A-10-2614-1&slc_lang=en&sid=1
Seyed Shahab
Banihashem
shb_banihashem@yahoo.com
100319475328460043077
100319475328460043077
No
Department of psychosomatic medicine, Taleghani Hospital Research Development Committee, Shahid Beheshti University of medical sciences, Tehran, Iran
Forough
Yousefi Saber
yousefiforough2@gmail.com
100319475328460043078
100319475328460043078
No
Department of Psychiatry, Taleghani Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Somayeh
Motazedian
somayehmotazedian@yahoo.com
100319475328460043079
100319475328460043079
No
Department of psychosomatic medicine, Taleghani Hospital Research Development Committee, Shahid Beheshti University of medical sciences, Tehran, Iran
Masoud
Mardani
mmardani@sbmu.ac.ir
100319475328460043080
100319475328460043080
No
Infectious Disease and Tropical Medicine Department, Faculty of Medicine of Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran
Alireza
Shamsi
ar.shamsi@sbmu.ac.ir
100319475328460043081
100319475328460043081
No
Department of psychosomatic medicine, Taleghani Hospital Research Development Committee, Shahid Beheshti University of medical sciences, Tehran, Iran
Maryam
Nazari
maryamnazari79@gmail.com
100319475328460043082
100319475328460043082
No
Department of Neurology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nastaran
Samani
nastaransamani1990@yahoo.com
100319475328460043083
100319475328460043083
No
Department of Psychiatry, Taleghani Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Arash
Danesh
arashdanesh1982@yahoo.com
100319475328460043084
100319475328460043084
Yes
Department of psychosomatic medicine, Taleghani Hospital Research Development Committee, Shahid Beheshti University of medical sciences, Tehran, Iran