Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1401
10
1
gregorian
2023
1
1
14
1
online
1
fulltext
en
Genotoxicity and cytotoxicity effects of X-rays on the oral mucosa epithelium at different fields of view: a cone beam computed tomography technique
Dentistry
Dentistry
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span style="background:white">Cone beam computed tomography (CBCT) is considered a common examination for dentistry problems. Cellular biology can be affected by exposure to ionizing radiations procedures. In this study, we aimed to assess the genotoxicity and cytotoxicity effects of CBCT dental examinations at two different fields of view (FOVs) in exfoliated buccal epithelial cells.</span><span style="font-size:9.0pt"></span></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span style="background:white">Sixty healthy adults participated in the current study. They were divided into two identical groups; CBCT with FOV of 6*6 cm2 and 8*11 cm2. Exfoliated oral mucosa cells were prepared immediately before and after 10-12 days of CBCT exposure. The cytological smears were stained with the Papanicolaou technique. The amounts of micronuclei and other cytotoxicity cellular changes (Pyknosis, Karyolysis, and Karyorrhexis) were evaluated. The variables of the parameters before and after CBCT examination in the two investigated FOVs were performed using Wilcoxon test and paired-samples t-test in SPSS software.</span><span style="font-size:10.0pt"></span></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span style="background:white">The micronuclei and other cytotoxic changes parameters before and after CBCT exposure for both FOVs (6*6 and 8*11 cm2) increased significantly (p<0.001). Furthermore, a significant difference (p<0.05) was observed between the investigated parameters at the two FOVs. Notably, the FOV of 8*11 cm2 had more side effects than that of 6*6 cm2. There were no statistically significant among males and females for both FOVs.</span><b><i><span style="color:blue"></span></i></b></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span style="background:white">CBCT examinations of dental disorders would increase the risks of inducing genetic damage. The cytotoxicity and chromosomal damage were considered in males and females in both investigated FOVs (6*6 and 8*11 cm2). In this regard, the use of CBCT must be following the ALARA principle.</span><b><i><span style="color:#0033cc"></span></i></b></span></span></span>
Cone beam computed tomography (CBCT), Oral mucosa epithelium, Genotoxicity, Cytotoxicity, Field of view (FOV)
121
127
http://caspjim.com/browse.php?a_code=A-10-2618-1&slc_lang=en&sid=1
Roghaieh
Faeli Ghadikolaei
saharfaeli@gmail.com
100319475328460040867
100319475328460040867
No
Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran
Hakimeh
Ghorbani
h.ghorbani@mubabol.ac.ir
100319475328460040868
100319475328460040868
No
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Maryam
Seyedmajidi
Ms_majidi79@yahoo.com
100319475328460040869
100319475328460040869
No
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran
Kourosh
Ebrahimnejad Gorji
K.E.Gorji@gmail.com
100319475328460040870
100319475328460040870
No
Department of Medical Physics Radiobiology and Radiation Protection, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Ehsan
Moudi
Ehsan.moudi@gmail.com
100319475328460040871
100319475328460040871
Yes
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Seyedali
Seyedmajidi
100319475328460040872
100319475328460040872
No
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran