en Gastroentrology Gastroentrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <i>Helicobacter pylori</i> infection is the most common cause of peptic ulcer disease. However, the prevalence rates of non-helicobacter pylori idiopathic peptic ulcers have increased over the past few years. This study aims to compare the characteristics of <i>Helicobacter pylori</i>-positive with idiopathic duodenal ulcers.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> A cross-sectional cohort study was conducted on 950 patients which were excluded from the analysis process duo to the concomitant presence of gastric ulcer, malignancy, Zollinger Ellison syndrome, Crohn&#39;s disease, esophageal varices, history of taking anti-Helicobacter pylori therapy, and history of taking NSAID or aspirin. Eventually, 647 subjects were enrolled for the analysis process. In this case, these subjects were divided into two groups: (I) <i>Helicobacter pylori</i>-positive ulcer group and (II) <i>Helicobacter pylori</i>-negative and non-NSAID (idiopathic) ulcer group.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> The findings showed that 417 patients (64.5%) had duodenal ulcers induced by <i>Helicobacter pylori</i>, and 111 patients (17.1%) had <i>Helicobacter pylori</i>-negative and non-NSAID ulcers. The mean ages of patients in <i>Helicobacter pylori</i>-positive and idiopathic ulcer groups were 39&plusmn;15 and 42&plusmn;17, respectively. In this case, 33 patients (29.7%) with idiopathic ulcers and 56 patients (25.1%) with <i>Helicobacter pylori</i>-positive ulcers had upper gastrointestinal bleeding. Also, 22 patients (21%) with idiopathic ulcers and 31 patients (16.5%) with <i>Helicobacter pylori</i>-positive ulcers had multiple duodenal ulcers<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The present study demonstrated that the idiopathic ulcers included 17.1% of duodenal ulcers. Also, it was concluded that patients with idiopathic ulcers were predominantly male with an age range older than the other group. In addition, patients in this group had more ulcers.</span></span></span> Idiopathic Ulcer, Helicobacter Pylori, Duodenal Ulcer, Endoscopy. 179 184 http://caspjim.com/browse.php?a_code=A-10-120-8&slc_lang=en&sid=1 Manizheh Ebrahimzadeh Pirshahid ebrahimzadeh.m97@yahoo.com 100319475328460041796 100319475328460041796 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Khadijeh Haghshenas kh.haghshenas@gmail.com 100319475328460041797 100319475328460041797 No Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran Mehrdad Kashifard mehrdadkashifard@yahoo.com 100319475328460041798 100319475328460041798 No Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran Javad Shokri-Shirvani j.shokri@mubabol.ac.ir 100319475328460041799 100319475328460041799 Yes Department of Internal Medicine, Babol University of Medical Sciences,