en Neurology Neurology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> The changes of plasma transcobalamin-II (TCII) and Zinc (Zn) Levels<b> </b>in epileptic patients are not clearly understood. The aim of the current study was to evaluate the plasma contents of TCII and Zn levels in newly&ndash;diagnosed epileptic seizure patients, long-standing grand mal epileptic patients following treatment with sodium valproate and healthy control group.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> Thirty patients aged 36.76&plusmn;12.91 years with newly&ndash;diagnosed and thirty long-standing grand mal epileptic patients aged 35.56 &plusmn;12.77 years were diagnosed based on the clinical symptoms. The control subjects were picked out from healthy individuals and matched to the patients, aged 36.30 &plusmn;12.80 years. Plasma Zn and TCN-2 was evaluated via spectrophotometry at 546 nm and 450 nm, respectively, using chimerical kits.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Plasma&nbsp;level of TCII in the newly&ndash;diagnosed epileptic seizures patients and long-standing grand mal epileptic patients were significantly increased, compared to the healthy controls [14.89 &plusmn;3.24 and 21.84&plusmn; 2.73 vs. 9.55&plusmn;1.24, (n=30)], respectively.&nbsp;Plasma level of Zn was decreased in the newly&ndash;diagnosed epileptic seizure patients, while it was increased in long-standing grand mal epileptic patients compared to the control group [69.28&plusmn; 6.41&nbsp;and 80.56 &plusmn;6.12 and vs.75.80&plusmn;1.59, (n=30)], respectively.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> This study suggests that sodium valproate may disrupt the homeostatic balance of TCII and Zn, and cause abnormality of their serum level in newly&ndash;diagnosed epileptic seizure patients and long-standing grand mal epileptic patients. Further research is recommended to identify the underpinning for these changes.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Transcobalamin-2, zinc, newly –diagnosed, long –standing grand mal, epileptic 199 204 http://caspjim.com/browse.php?a_code=A-10-176-4&slc_lang=en&sid=1 Amene Aman-Mohammady rohanresearch88@gmail.com 100319475328460041811 100319475328460041811 No Babol university of Medical sciences, Babol, Iran Payam Saadat sepanta1968@yahoo.com 100319475328460041812 100319475328460041812 Yes Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Durdi Qujeq rohanresearch88@gmail.com 100319475328460041813 100319475328460041813 No Department of Biochemistry, Babol University of Medical Sciences, Babol, Iran Karimollah Hajian-Tilaki drhajian@yahoo.com 100319475328460041814 100319475328460041814 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Kiarash Saleki kiarash_saleki@icloud.com 100319475328460041815 100319475328460041815 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran