en Hematology Hematology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Chronic lymphocytic leukemia (CLL) can transform into fast growing lymphoma for diffuse large B-cell lymphoma (DLBCL) called Richter&#39;s syndrome (RS), which is commonly related to an existence of large B-cells with equal or larger size than macrophage nuclei or more than twice those of normal lymphocyte. We conducted a systematic review of the existing literature to assess the clinical efficacy of auto-HCT for patients with RS.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> We searched 4 main databases; EMBASE, Google Scholar, Scopus, PubMed and Web of Science and was done on December 26,2021. All analyses in this study were performed by Stata software and this review was reported in accordance with PRISMA 2020.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Data was extracted from 4 articles; the total number of patients was reported to be 110. Based on the meta-analysis findings, pooled overall survival rate was 56.36% (95%CI= (46.98 &ndash; 65.31). In figure 2, the forest plot of combined results is shown.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Despite the use of common treatment regimens such as chemo immunotherapy and the availability of novel therapies including B-cell receptor inhibitors and rituximab-cyclophosphamide-hydroxydaunorubicin-Oncovin-prednisone (CHOP-R) regimen, the status of disease progression and recovery in RS cases is still not strong enough.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Richter, Autologus, Hematopoietic transplantation, Efficacy, Systematic review 1 9 http://caspjim.com/browse.php?a_code=A-10-2349-13&slc_lang=en&sid=1 Mehran Sharifi m_sharifi.86374@yahoo.com 100319475328460040771 100319475328460040771 No Department of Internal Medicine , school of medicine , Cancer prevention Research Center , Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran Ziba Farajzadegan zfarajzadegan61@gmail.com 100319475328460040772 100319475328460040772 No Department of Community and Preventive Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Saeid Rezaei Jouzdani s.rezaei.jouzdani@gmail.com 100319475328460040773 100319475328460040773 Yes Department of Internal Medicine , school of medicine , Cancer prevention Research Center , Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran