Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1402
2
1
gregorian
2023
5
1
14
3
online
1
fulltext
en
Evaluation and comparison of therapeutic effects of probiotics and colloidal bismuth subcitrate on abdominal bloating
Gastroentrology
Gastroentrology
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Functional abdominal bloating is one of the functional gastrointestinal disorders (FGIDs). Here, we aimed to investigate and compare the effects of probiotics and colloidal bismuth subcitrate on abdominal bloating.</span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This was a double-blinded randomized clinical trial performed on 125 patients with functional abdominal bloating in Isfahan in 2020-2021. At the beginning of the study, information on the frequency of abdominal bloating, its severity, the occurrence of early satiety, frequency of borborygmus, frequency of belching, and the frequency of defecation per week was collected. Patients were divided into 3 groups receiving familact probiotic pills that contained 7 bacterial strains, colloidal bismuth subcitrate tablets, and placebo pills for 4 weeks. Afterwards, the frequency and severity of abdominal bloating and other symptoms were compared.<span style="font-size:10.0pt"></span></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> After 2 weeks, patients in the probiotic group had a significantly lower frequency of abdominal bloating compared to other groups (P= 0.006). After 4 and 8 weeks, patients in the probiotic group and bismuth group had a lower frequency of bloating )3.18±3.02, 4.11±3.34) compared to placebo (5.10±3.54) (P= 0.001 and P= 0.037, respectively). During the study, patients in the probiotic group had a significantly lower bloating severity (41.90% had no symptom) compared to bismuth and placebo groups (12.50 ,12.00% had no symptom) (p< 0.05). The frequency of borborygmus was significantly lower in the probiotic group after 2 and 4 weeks during the study compared to other groups (1.62±0.2 Vs 2.69±0.3, 2.45±0.3 ) (P= 0.010 and P= 0.013, respectively).<span style="font-size:10.0pt"></span></span><br>
<b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> According to our data, consumption of probiotics improves the frequency and severity of abdominal bloating and reduces borborygmus. Colloidal bismuth subcitrate also has significant effects.</span></span>
Abdominal bloating, functional gastrointestinal disorder, Probiotic, Bismuth, clinical trial
518
525
http://caspjim.com/browse.php?a_code=A-10-2674-1&slc_lang=en&sid=1
Maryam
Soheilipour
maryamsoheilip@med.mui.ac.ir
100319475328460043051
100319475328460043051
No
Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran
Elham
Tabesh
tabesh.elham@gmail.com
100319475328460043052
100319475328460043052
No
Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran
Soheila
Najmi
so.najmi82@gmail.com
100319475328460043053
100319475328460043053
Yes
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mostafa
Raisi
mostafaraisi@yahoo.com
100319475328460043054
100319475328460043054
No
Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Peyman
Adibi
adibi@med.mui.ac.ir
100319475328460043055
100319475328460043055
No
Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran