en Obstetrics & Gynicology Obstetrics & Gynicology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Dermatofibrosarcoma protuberans (DFSP) is a soft tissue tumor that originates from deep layers of the dermis and mainly is common in young adults to middle age. This tumor is rare in the vulva.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case Presentation:</span></i></b> A 53-year-old multiparous menopause female had complained of asymptomatic swelling of the right labia major. Dermatofibrosarcoma protuberans was reported in primary tumor resection.&nbsp; Six months later, rapid growing mass recurred in the vulva. The patient underwent radical Vulvectomy and resection of the margin of about 2-3 cm along with bilateral Inguinofemoral lymphadenectomy. The margins of the mass were negative in the frozen section. Microscopic examination revealed that hypercellular neoplasm in dermis comprising monomorphic spindle cells with high mitotic activity, some hyperchromatic nuclei arranged in palisading fashion. Microscopic and IHC study confirmed the conversion of dermatofibrosarcoma protuberans to fibrosarcoma.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b><b> </b>This case was presented due to the rarity of dermatofibrosarcoma protuberance in the vulva and pathologic conversion to fibrosarcoma.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Dermatofibrosarcoma Protuberan, Fibrosarcomatous, Vulva, Therapeutics, Iran, Neoplasms 572 576 http://caspjim.com/browse.php?a_code=A-10-2319-1&slc_lang=en&sid=1 Maliheh Arab drmarab@sbmu.ac.ir 100319475328460043091 100319475328460043091 Yes Department of Gyneco-Oncology, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nafiseh Faghih nafish.faghih@sbmu.ac.ir 100319475328460043092 100319475328460043092 No Department of Gyneco-Oncology Taleghani Medical Center, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran Mahsa Asghari mahsaasghari96@yahoo.com 100319475328460043093 100319475328460043093 No Shahid Beheshti University of Medical Sciences. Tehran Mona Agha Majidi Aghamajidimona@gmail.com 100319475328460043094 100319475328460043094 No Shahid Beheshti University of Medical Sciences. Tehran Behnaz Ghavami behnaz_ghavami@yahoo.com 100319475328460043095 100319475328460043095 No Tehran University of Medical Sciences Tehran, Iran Shahla Noori Ardebili Dr.shahlanooriardebili@gmail.com 100319475328460043096 100319475328460043096 No Atieh Hospital, Tehran, Iran