Caspian Journal of Internal Medicine

en A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease Gastroentrology Gastroentrology Review Article Review Article Background: In the pathogenesis of inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron’s disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that increased its transcriptional activity. This study, therefore, used a systematic review and meta-analysis to examine the relationship between the RAGE gene polymorphism and the risk of IBD. Methods: Databases such as PubMed, Scopus, and Cochrane library were searched to identify the relationship between RAGE gene polymorphisms and IBD susceptibility. We identified three Single Nucleotide Polymorphism (SNPs) (RAGE-429T/C, 374T/A, and G82S). The data were analyzed by RevMan 5.4. Results: Four studies (932 cases/1366 controls) were included. The findings showed no relationship between RAGE –429T/C and –G82S polymorphisms and the risk of IBD in all genetic models significantly. TT genotype of RAGE –374T/A polymorphisms was related to increased CD risk (OR=1.37; 95%CI=1.04-1.81; P=0.02), while TA genotype was determined to be a protective factor (OR=0.75; 95%CI=0.57-0.99; P=0.04). In UC, A allele of RAGE -374T/A was related to increase risk (OR=1.26; 95%CI=1.04-1.53; P=0.02), while T allele was determined to decrease risk (OR=0.79; 95%CI= 0.65-0.96; P=0.02). Conclusions: Our findings demonstrated that TT genotype and A allele of RAGE -374T/A polymorphisms were related to CD and UC risks, respectively, while the TA genotype and T allele possibly had a protective effect. RAGE –429T/C and RAGE –G82S polymorphisms were not related to increased IBD risk.   inflammatory bowel disease, advanced glycation end products receptor, genetic polymorphisms, meta-analysis, systematic review 412 424 http://caspjim.com/browse.php?a_code=A-10-2702-1&slc_lang=en&sid=1 Ratih Puspita Febrinasari ratihpuspita@staff.uns.ac.id 100319475328460042948 100319475328460042948 Yes Department of Pharmacology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Indah Sagitaisna Putri indahsagitaisna18@gmail.com 100319475328460042949 100319475328460042949 No Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Bastomy Eka Rezkita bastomyeka@gmail.com 100319475328460042950 100319475328460042950 No Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Steven Irving irving.steven21@gmail.com 100319475328460042951 100319475328460042951 No Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia Akhmad Azmiardi aazmiardi@gmail.com 100319475328460042952 100319475328460042952 No School of Health Sciences Mamba'ul 'Ulum, Surakarta, Indonesia Rabbinu Rangga Pribadi rabbinuranggap@gmail.com 100319475328460042953 100319475328460042953 No Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia Marcellus Simadibrata prof.marcellus.si@gmail.com 100319475328460042954 100319475328460042954 No Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia Yulia Sari yuliasari_fk@staff.uns.ac.id 100319475328460042955 100319475328460042955 No Department of Parasitology, Faculty of Medicine, Universitas Sebelas Maret, Indonesia