en Cardiology Cardiology Original Article Original Article <span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:blue">Background</span></span></i></b><i><span style="font-size:10.0pt"><span style="color:blue">:</span></span></i><span style="font-size:10.0pt"> Late</span><span style="font-size:10.0pt"> in pregnancy or soon after delivery, peripartum cardiomyopathy (PPCM) which is an uncommon type of cardiomyopathy, can develop. To assess the association between the level of irisin expression and <span style="background-color:#ffffff;">(</span><span style="background:red"><span style="background-color:#ffffff;">FNDC5</span></span><span style="background-color:#ffffff;">) (rs</span>3480) gene polymorphism with peripartum cardiomyopathy.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:blue">Methods:</span></span></i></b> <span style="font-size:10.0pt">This is a case control study included a thirty female patients with new-onset PPCM and sixty healthy females at the at the peripartum period in same time window for PPCM as a control.&nbsp; For each patient, comprehensive medical history was taken, full clinical assessment was done, ECHO.<span style="background-color:#ffffff;">, </span></span><span style="font-size:10.0pt"><span style="background:red"><span style="background-color:#ffffff;">FNDC5</span></span></span><span style="font-size:10.0pt"><span style="background-color:#ffffff;"> (rs34</span>80) & Irisin assay.</span><span style="font-size:10.0pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:blue">Results:</span></span></i></b> <span style="font-size:10.0pt">The left ventricle end diastolic dimensions &left atrium diameters were statistically significant higher in patients&rsquo; group than controls&rsquo; group (P=0.000 for all), Also left ventricular ejection fraction (%) was statistically significant lower in patients than controls and as regards irisin, its Mean &plusmn;SD was lower in patient group than control group (8.44&plusmn;1.1 vs 10.65&plusmn;2.31) with (p <0.001) which is considered a significant difference statistically.</span><span style="font-size:10.0pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><b><i><span style="font-size:10.0pt"><span style="color:blue">Conclusion</span></span></i></b><i><span style="font-size:10.0pt"><span style="color:blue">:</span></span></i> <span style="font-size:10.0pt">Irisin level was lower in peripartum cardiomyopathic patients when compared with normal individuals and regarding its genotype, the homotype A/A was higher than homotype G/G.</span><span style="font-size:10.0pt"></span></span></span></span><br> <br> &nbsp; FDNC5 Polymorphism , Peripartum Cardiomyopathy, Irisin 66 75 http://caspjim.com/browse.php?a_code=A-10-2715-1&slc_lang=en&sid=1 Ali Altaher dr.ali.altaher30@gmail.com 100319475328460046495 100319475328460046495 Yes Sohag faculty of medicine Mohamed eid moh.eid1979@gmail.com 100319475328460046496 100319475328460046496 No Sohag faculty of medicine Hesham moslem h.hefny1974@gmail.com 100319475328460046497 100319475328460046497 No Sohag faculty of medicine Amal Ali dramalsalama2018@yahoo.com 100319475328460046498 100319475328460046498 No Aswan faculty of medicine Samar Mustafa Smmk.mostafa@yahoo.com 100319475328460046499 100319475328460046499 No Sohag faculty of medicine Amera morad ameramoradfoad@gmail.com 100319475328460046500 100319475328460046500 No Sohag faculty of medicine