en Gastroentrology Gastroentrology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Among mesenchymal tumors arising in the gastrointestinal tract, gastrointestinal stromal tumors are the most common. GISTs that do not have metastatic spread are treated surgically. Our case report aims to describe a newer & less invasive approach for resection of GISTs & early gastrointestinal tumors.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case Presentation:</span></i></b> An Iranian woman 41 years old with stomach stromal tumor is presented. Her complaint was minor epigastric discomfort. Tumor en-bloc resection was performed using a hybrid endoscopic-laparoscopic approach. She was doing very well & discharged the day after the operation.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b><b> </b>GISTs and early gastrointestinal tumors can be treated with hybrid endoscopic and laparoscopic en-bloc resections instead of invasive surgery.</span></span></span><br> &nbsp; Gastrointestinal Stromal tumors, Endoscopy, Laparoscopy, Neoplasms 169 173 http://caspjim.com/browse.php?a_code=A-10-1091-1&slc_lang=en&sid=1 Seyed Hassan Abedi h.abedi@doctor.com 100319475328460050609 100319475328460050609 No Clinical Research Development Unit of Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. Pedram Beigvand Pedrambigvand@gmail.com 100319475328460050610 100319475328460050610 No Clinical Research Development Unit of Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. Reza Mortazavi rohanresearch88@gmail.com 100319475328460050611 100319475328460050611 No Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Sara Babazade babazadeh.sara@gmail.com 100319475328460050612 100319475328460050612 No Department of Pathology, School of Medicine, Babol University of Medical Sciences, Iran Ali Zahedian alizahed20@yahoo.com 100319475328460050613 100319475328460050613 Yes Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran