en Dermathology Dermathology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> End-stage renal disease (ESRD) is a serious chronic disease that affects many organ systems. Skin manifestations that are commonly seen in ESRD can significantly impair the quality of life in these patients. Early recognition and management of mucocutaneous disorders can improve quality of life and decrease morbidity. This study aimed to evaluate the skin manifestations in ESRD patients undergoing hemodialysis.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> In this cross-sectional study 150 patients undergoing hemodialysis in the Nephrology Department of Shahid-Beheshti Hospital in Babol were enrolled. The demographic and clinical data were assessed. Analysis was done by SPSS 22 and significance level was under 0.05.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> The mean duration of hemodialysis was 8.7 months. The most common skin findings in patients include xerosis 84.7%, pallor 82.7%, pruritus 67.3%, hyperpigmentation 40%, purpura 28%. Skin infections were detected in 36% of patients (fungal 28%, bacterial 10.7%, and viral 5.3%). Nail, hair and mucosal changes were observed among 65.3%, 38% and 17.3% of patients respectively. No significant correlation was detected between skin findings and duration of dialysis.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The findings of the present study showed that skin manifestations are highly prevalent among patients with ESRD. Prompt diagnosis and management of the dermatological disorders may improve the quality of life in the affected patients.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; Cutaneous manifestation, Hemodialysis, End-stage renal disease 728 731 http://caspjim.com/browse.php?a_code=A-10-1811-3&slc_lang=en&sid=1 Azar Shirzadian Kebria shirzadiank@gmail.com 100319475328460044954 100319475328460044954 Yes Department of Dermatology, Babol University of Medical Sciences, Babol, Iran Zeinab Aryanian z_aryanian@yahoo.com 100319475328460044955 100319475328460044955 No Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran Amin Choobdar dr.amin.choobdar@gmail.com 100319475328460044956 100319475328460044956 No Department of Dermatology, Babol University of Medical Sciences, Babol, Iran Roghayeh Akbari roghayeh.akbari@yahoo.com 100319475328460044957 100319475328460044957 No Department of Nephrology, Babol University of Medical Sciences, Babol, Iran