en Nephrology Nephrology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;">Diabetes mellitus and its complications are a known public health problem nowadays. Diabetic nephropathy is one of the main complications a<span style="line-height:14pt">nd the result of multiple mechanisms, including: activation of the renin-angiotensin-aldosterone system, formation of advanced glycation end products and chronic inflammation that led to glomerular and tubulo-interstitial damage producing mesangial expansion and glomerulosclerosis, which finally results in chronic kidney disease. Early detection of diabetic nephropathyis essential for adequate intervention to stop, or at least sloww down its progression. Multiple markers have been described, not only the classic ones such as serum creatinine, urea, and albuminuria, but at this point also novel biomarkers such as neutrophil gelatinase-associated lipocalin, tumor necrosis factor 1 receptor and monocyte chemoattractant protein-1, among others. The aim of this article was to provide an update review of the role of biomarkers in the diagnosis of diabetic nephropathy.</span></span></span><br> &nbsp; Diabetes mellitus, diabetic nephropathy, biomarkers, diagnosis 382 391 http://caspjim.com/browse.php?a_code=A-10-1924-2&slc_lang=en&sid=1 Marcio Concepción-Zavaleta marcio_conc_zav@outlook.es 100319475328460049276 100319475328460049276 Yes Universidad Científica del Sur. Lima, Peru Juan Quiroz-Aldave juan.sb491@gmail.com 100319475328460049277 100319475328460049277 No Division of Medicine, Hospital de Apoyo Chepén, Peru Jacsel Suarez Rojas jacsel.suarez@gmail.com 100319475328460049278 100319475328460049278 No Division of Endocrinology. Santa Rosa Hospital, Southern Scientific University, Lima, Peru José Paz-Ibarra jose.paz1@unmsm.edu.pe 100319475328460049279 100319475328460049279 No Division of Endocrinology, Edgardo Rebagliati Martins National Hospital, Lima, Peru Pela Roseboom pjap.rose@gmail.com 100319475328460049280 100319475328460049280 No Department of Medicine, Cesar Vallejo Mendoza Hospital, Santiago de Chuco, Peru Sofia Ildefonso-Najarro sofiaildefonso23@gmail.com 100319475328460049281 100319475328460049281 No Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima, Peru Denis Cribilleros Zevallos dns_10_23@hotmail.com 100319475328460049282 100319475328460049282 No Division of Nephrology, National Center of Renal Heath, Lima, Peru Francisca Zavaleta-Gutiérrez paquitamed@hotmail.com 100319475328460049283 100319475328460049283 No Division of Neonatology, Belén Hospital of Trujillo, Trujillo, Peru Julia Coronado-Arroyo juliacristinacoronado@gmail.com 100319475328460049284 100319475328460049284 No Department of Obstetrics and Gynecology, Edgardo Rebagliati Martins National Hospital, Lima, Peru Luis Concepción-Urteaga luisconcepcionurteaga@hotmail.com 100319475328460049285 100319475328460049285 No Department of Medicine, Hospital Regional Docente of Trujillo, Trujillo, Peru