en Nephrology Nephrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> The increase in serum phosphorus level is an independent risk factor for mortality in patients with chronic renal failure or undergoing dialysis due to end-stage renal disease. (1) Proton pump inhibitors (PPI) are the general name given to agents used to suppress stomach acid. In this study, the clinical benefit of using PPIs in addition to drugs used for phosphorus control was investigated.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="TR">153 patients with end-stage renal disease were included in the study. The data of the patients who had been on hemodialysis for at least 6 months and using calcium acetate for at least 1 month were recorded in the SPSS 21 program. The patients were analyzed in </span>two<span lang="TR"> groups according to whether they used PPI or not.</span> A<span lang="TR">namnesis,</span> p<span lang="TR">atient follow-up</span>,<span lang="TR"> laboratory</span>,<span lang="TR"> and treatment forms</span> collected from<span lang="TR"> hemodialysis</span> centers<span lang="TR"> were used</span>.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Of the 153 patients in the study, 49% were males and the mean age was 65.11&plusmn;11.23. The mean duration of patients on dialysis was 48.5 months. Hypertension was found to be the most common comorbidity with 75.8% prevalence among the patients. The mean phosphorus levels of the patients using calcium acetate together with PPI were found to be approximately 1.2 mg/dl lower (p= 0.000).<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> It should be taken into account that the use of PPI together with calcium acetate, which is still common as a phosphorus binder in developing countries, can contribute to controlling phosphorus levels.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; Renal Failure, Hyperphosphatemia, PPI, Hemodialysis, Calcium Acetate 737 740 http://caspjim.com/browse.php?a_code=A-10-2898-1&slc_lang=en&sid=1 Deniz Çekiç decekic@gmail.com 100319475328460044969 100319475328460044969 Yes Department of Internal Medicine, Sakarya Research and Training Hospital, Adapazari, Sakarya, Turkey Savaş Sipahi savassipahi@yahoo.com 100319475328460044970 100319475328460044970 No Department of Nephrology, Sakarya Research and Training Hospital, Adapazari, Sakarya, Turkey Mehmet Emir Arman me4rman@gmail.com 100319475328460044971 100319475328460044971 No Department of Internal Medicine, Sakarya Research and Training Hospital, Adapazari, Sakarya, Turkey