en Nephrology Nephrology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Ifosfamide-induced Fanconi syndrome is a relatively infrequent complication that generally occurs in young patients with a high cumulative dose of ifosfamide; and is commonly characterized by glycosuria, proteinuria, electrolyte abnormalities, and a normal anion gap metabolic acidosis.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case Presentation:</span></i></b> In this study, we present the case of a 16-year-old male patient with of osteosarcoma of the right femur with pulmonary metastasis, who received ifosfamide as part of chemotherapy 1 year and 2 months ago and required hospitalization for cellulitis. During inpatient management, he presented with hypokalemia, hypophosphatemia, polyuria, glycosuria, and proteinuria, by which he was diagnosed with Fanconi syndrome and nephrogenic diabetes insipidus, induced by ifosfamide. Management was focused on the control of the internal environment and use of potassium supplements and potassium-sparing diuretics.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b><b> </b>Patients receiving ifosfamide should be periodically monitored for kidney function and internal environment to detect any potential complications. It is thus important to carefully observe the cumulative dose of ifosfamide to prevent its associated nephrotoxicity, since its appearance can impoverish the prognosis in patients with neoplasms. Therefore, physicians should always be aware about the possibility of nephrotoxicity development.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Fanconi syndrome, Nephrogenic Diabetes Insipidus, Ifosfamide 743 747 http://caspjim.com/browse.php?a_code=A-10-1924-3&slc_lang=en&sid=1 Marcio Concepción-Zavaleta marcio_conc_zav@outlook.es 100319475328460050270 100319475328460050270 Yes Universidad Científica del sur, Lima, Perú Guillermo Ramos-Torres lie252555@hotmail.com 100319475328460050271 100319475328460050271 No Department of Emergency Medicine, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú Juan Quiroz-Aldave jquirozaldave@hotmail.com 100319475328460050272 100319475328460050272 No Department of Medicine, Hospital de Apoyo Chepén, Perú María Durand-Vásquez mdurandvasquez@hotmail.com 100319475328460050273 100319475328460050273 No Department of Family Medicine, Hospital de Apoyo Chepén, Perú Sofía Ildefonso-Najarro sofiaildefonso23@gmail.com 100319475328460050274 100319475328460050274 No Department of Endocrinology, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú Elena de Jesús Alvarado-León 100319475328460050275 100319475328460050275 No College of Medicine, National University of Trujillo, Lima, Perú Francisca Zavaleta-Gutiérrez paquitamed@hotmail.com 100319475328460050276 100319475328460050276 No Department of Pediatric and Neonatology, Hospital Belén de Trujillo, Perú Luis Concepción-Urteaga luisconcepcionurteaga@hotmail.com 100319475328460050277 100319475328460050277 No College of Medicine, National University of Trujillo, Perú José Paz-Ibarra jose.paz1@unmsm.edu.pe 100319475328460050278 100319475328460050278 No Department of Endocrinology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Perú