en Endocrinology Endocrinology Short Communication Short Communication <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b><b> </b>Despite the numerous articles discussing the relationship between diabetes mellitus type 2 (DMT2) and chronic Helicobacter pylori (H. pylori) infection the results have been inconsistent, necessitating further research. This study investigated the coexistence of Helicobacter pylori infection and DMT2.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> We conducted a study in selected laboratories in Tehran, measuring the H.Pylori stool antigen (HpSA) in individuals referred by physicians for a glycosylated hemoglobin A1c (HbA1c) test<span lang="EN">. </span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Out of the 2500 patients who were referred to randomly selected laboratories, a total of 2025 (81%) patients had serum HbA1c levels above 6.5%. of 2025 patients with HbA1c levels above 6.5%, 1321 (52.84%) had HpSA in their stool. No significant gender difference was observed, with a mean age &plusmn; SD, 48.65 &plusmn; 7.55. HpSA was positive in 52.84% of the DM group, while in the non-DM group, HpSA was positive in 37.36% of cases. Fecal antigen titers are not related to gender (P = 0.274) but are related to age (r = 0.213, P=0.034)<span lang="EN">.</span><b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b> Long-term infection with Helicobacter pylori may be significantly associated with elevated HgA1c.Testing for H. pylori infection, regular monitoring of blood sugar and HbA1c levels in high-risk people can prevent DMT2.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; HbA1c, Helicobacter pylori infection, Type 2 diabetes 172 175 http://caspjim.com/browse.php?a_code=A-10-2141-2&slc_lang=en&sid=1 Mehrdad Haghighi Mehrdad_pana@yahoo.com 100319475328460046590 100319475328460046590 No Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mehdi Goudarzi Gudarzim@yahoo.com 100319475328460046591 100319475328460046591 No Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Abdolreza Babamahmoodi rmmsabm@gmail.com 100319475328460046592 100319475328460046592 Yes Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran