en Gastroentrology Gastroentrology Original Article Original Article <p>  <font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Background: </span></i></b><span lang="EN-US" style="font-size: 10pt">Low bone mass is a frequent complication of chronic inflammatory disease. The pathogenesis of osteoporosis in chronic inflammatory disease may be secondary to releases of cytokines such as TNF-</span></font><span lang="EN-US" style="font-family: Symbol font-size: 10pt"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol" size="2">a</font></span></span><span lang="EN-US" style="font-size: 10pt"><font face="Times New Roman"> and IL6. Chronic gastritis due to <i>helicobacter pylori</i> (HP) infection may lead to decreased bone mineral density (BMD) and predispose patients to osteoporosis. The objective of this study was to determine the BMD status in HP positive patients with gastritis versus HP negative cases.<b><i><span style="color: blue"><o:p /></span></i></b></font></span><font face="Times New Roman" size="3"> </font></p><p><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Methods:</span></i></b><span lang="EN-US" style="font-size: 10pt"> In this cross-sectional study, we enrolled 967 participants aged 60 years old and more from Amirkola Health Study Ageing Project. Seven-hundred and fifty eight HP positive and 209 HP negative patients were analyzed. BMD was measured by dual-energy x-ray absorptiometry (DXA) method in the spine and femoral neck in all participants.<span class="longtext"><span style="background: white color: black"><o:p /></span></span></span></font><font face="Times New Roman" size="3"> </font></p><p><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Results:</span></i></b><span lang="EN-US" style="font-size: 10pt"> The mean age in HP+ and HP- negative patients was 68.3±6.8 and 69.3±7.4 years, respectively. BMD g/cm2 in the spine and femoral neck did not differ between the two groups (P=0.19 and 0.22 respectively). The prevalence of osteoporosis did not also differ across the two groups as well. There was no relationship between the level of antibodies against HP and BMD.</span></font></p><p><font face="Times New Roman"><span lang="EN-US" style="font-size: 10pt"></span></font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Conclusion: </span></i></b><span lang="EN-US" style="font-size: 10pt">According to the findings of this study, H. pylori infection is not associated with BMD changes in the elderly population. <o:p /></span></font></p><font face="Times New Roman" size="3"> </font> Helicobacter pylori, Osteoprosis, Bone mineral density, Elderly patients 62 66 http://caspjim.com/browse.php?a_code=A-10-120-3&slc_lang=en&sid=1 Mahdiye Fotouk-kiai 10031947532846003098 10031947532846003098 No Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran. Seyed Reza Hoseini 10031947532846003099 10031947532846003099 No Social Determinates of Health Research Center, Health Research Institute, Babol University of Medical Sciences Babol, Iran. Neda Meftah 10031947532846003100 10031947532846003100 No . Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran. Reza Ghadimi 10031947532846003101 10031947532846003101 No Social Determinates of Health Research Center, Health Research Institute, Babol University of Medical Sciences Babol, Iran. Ali Bijani 10031947532846003102 10031947532846003102 No Social Determinates of Health Research Center, Health Research Institute, Babol University of Medical Sciences Babol, Iran. Hajighorban Noreddini 10031947532846003103 10031947532846003103 No Department of Radiology, Babol University of Medical Sciences, Babol, Iran. Hamidreza Nematollahi 10031947532846003104 10031947532846003104 No Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran. Javad shokri-shirvani javad.shokry@gmail.com 10031947532846003105 10031947532846003105 Yes Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran