en Internal Internal Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-GB">The aim of this study was to find the difference between the liver function test (LFT) and hepatorenal index (HRI), before and after the administration of <i>Prunus mume</i> (PM) and choline i.e., to find the predictors of the non-alcoholic fatty liver disease (NAFLD) severity according its HRI, during the three-month follow-up period</span>.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="EN-GB">LFT, glucose, and lipid tests were determined in 168 NAFLD patients, at baseline and after three-month drug treatment. </span>HRI was calculated by Image J software analyzing the ultrasound images, and according its value, 3 groups of NAFLD were formed.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span lang="EN-GB">The HRI at baseline (1.3598&plusmn;0.1744) and after 3 months therapy (1.3061&plusmn;0.1923) differs significantly (p<0.0001). Plasma glucose (FPG) (p<0.0001), glycated hemoglobin (HbA1c) (P=0.002), alanine aminotransferase (ALT) (p<0.0001), aspartate aminotransferase (AST) (P=0.0006), gamma-glutamil transferase (&gamma;-GT) (P=0.0053), high density lipoprotein cholesterol (HDL-Ch) (p<0.0001) and triglycerides (P=0.041) differ significantly, too. HRI is positively correlated with: HbA1c (P=0.035), ALT (P=0.002), AST (P=0.003), &gamma;-GT (P=0.043), and triglycerides (P=0.002) and inversely correlated with HDL-Ch (P=0.011). In multiple regression results (standard coefficient and p-value), the independent predictors for HRI in NAFLD patients were: HbA1c (0.1443, 0.0004), ALT (0.001142, 0.0081), triglycerides (0.0431, 0.0235) and &gamma;-GT (0.001376, 0.0329).</span><span style="font-size:10.0pt"></span></span><br> <b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-GB">Three-month administration of PM and choline have beneficial effects on the regulation of glucose and lipid metabolism (HDL-Ch), and on LFT. This plant extract significantly reduces the levels of FPG, HbA1c, ALT, AST, &gamma;-GT, triglycerides and increases HDL-Ch. The triglycerides, ALT, &gamma;-GT and HbA1c are positive independent predictors for the severity of NAFLD</span></span></span> Prunus mume, Choline, Non-alcoholic fatty liver disease, Hepatorenal index, Functional liver tests, Ultrasonography. 161 171 http://caspjim.com/browse.php?a_code=A-10-1189-2&slc_lang=en&sid=1 Petar Avramovski avramovski@gmail.com 100319475328460046583 100319475328460046583 Yes Clinical hospital, Bitola, North Macedonia Miroslav Lazarevski mirolazar2407@gmail.com 100319475328460046584 100319475328460046584 No City General Hospital 8th September, Department of internal medicine Maja Avramovska pom_cool@yahoo.com 100319475328460046585 100319475328460046585 No Clinical Hospital - Bitola, Partizanska b.b. 7000 Bitola Stefan Talev stefantalev@hotmail.com 100319475328460046586 100319475328460046586 No Department of chirurgie, Clinical Hospital - Bitola, Julijana Petrovska jpetro@hotmail.com 100319475328460046587 100319475328460046587 No Department of clinical and interventional gastroenterology, Partizanska b.b. 7000 Bitola, North Macedonia. Vesna Siklovska siklov@yahoo.com 100319475328460046588 100319475328460046588 No Specialist of radiology, Clinical hospital Bitola Kosta Sotiroski ksotir2@yahoo.com 100319475328460046589 100319475328460046589 No Faculty of Economics - Prilep,