en Oncology Oncology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Multiple cystic brain metastases are a rare form of cancer dissemination and usually originate from adenocarcinomas of the lung and breast. Managing these lesions is challenging, and cyst drainage plays an essential role in reducing intracranial pressure. This article presents a case of multiple cystic brain metastases from lung adenocarcinoma. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case Presentation:</span></i></b> A 40-year-old female with a two-year history of stage IV lung adenocarcinoma presented with debilitating progressive neurologic symptoms. Imaging studies showed multiple cystic lesions on brain MRI most consistent with brain metastases. She underwent a craniotomy to drain the biggest cysts, followed by whole-brain radiotherapy (WBRT). The patient experienced dramatic alleviation of symptoms. Following a year of follow-up, she had no neurological symptoms. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b><b> </b>Despite the rarity of cystic brain metastases, these lesions should be ruled out in case of signs of increased intracranial pressure in a patient with a history of malignant disease.</span></span></span><br> &nbsp; adenocarcinoma, brain metastasis, cystic lesions, lung cancer 200 204 http://caspjim.com/browse.php?a_code=A-10-2647-3&slc_lang=en&sid=1 Danial Fazilat-Panah drfazilatpanah@gmail.com 100319475328460055906 100319475328460055906 No Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Habibollah Hasani habib_1349@yahoo.com 100319475328460055907 100319475328460055907 No Clinical Research Development unit of Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Mazandaran, Iran Ali Alizadeh Khatir alizadeh.ali83@yahoo.com 100319475328460055908 100319475328460055908 No Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandaran, Iran Ali Shabestani Monfared monfared1345@gmail.com 100319475328460055909 100319475328460055909 No Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Hamid Fallah Tafti hmd_fallah@yahoo.com 100319475328460055910 100319475328460055910 No Radiotherapy Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Yazd, Iran Nahid Ahmadi Nahidahmadi1989@gmail.com 100319475328460055911 100319475328460055911 No Cancer Research Center, Health Research Institute, University of Medical Sciences, Babol, Iran Siamak Kazemi Soufi dr.s.kazemisufi@gmail.com 100319475328460055912 100319475328460055912 No Department of Orthopedics, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran Ali Emadi Torghabeh emadiTA@mums.ac.ir 100319475328460055913 100319475328460055913 No Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Babak PeyroShabany b.p.shabany@gmail.com 100319475328460055914 100319475328460055914 No Department of Internal Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran Hassan Younesi Ghale hassan_younesi@yahoo.com 100319475328460055915 100319475328460055915 No Babol University of Medical Sciences, Babol, Iran Sara Rasta srasta1986@gmail.com 100319475328460055916 100319475328460055916 No Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran Seyed Alireza Javadinia Javadiniaa941@mums.ac.ir 100319475328460055917 100319475328460055917 No Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran Maedeh Alsadat Fatemi mrsfatemi@yahoo.com 100319475328460055918 100319475328460055918 Yes Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran