en Oncology Oncology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:13.7pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Oral candidiasis is the most common infection of oral mucosa caused by <i>Candida albicans</i>. A common predisposing factor for candidiasis is immune system suppression in specific diseases such as AIDS and various cancers. This study aimed to analyze the effect of Kefir probiotic products on the count of <i>C. Albicans</i> in the saliva of chemotherapy patients. </span><br> <span style="line-height:13.7pt"><b><i><span style="color:blue">Methods:</span></i></b> In this single-blinded clinical trial, 50 patients were selected who have signed informed consent forms. Patients aged 20-60 years with colon or breast cancer who received the same chemotherapy regimen were included and those with a history of radiation therapy, underlying diseases, using antibiotics, anti-fungal and GCSF medicines were excluded. Matched patients in test and control groups received 100 ccs Kefir probiotic and mineral water, respectively at a specific daily time for five weeks. Blood and saliva samples were collected in five steps. Data were analyzed using SPSS Version 21 and the significance level was set at p< 0.05. </span><br> <span style="line-height:13.7pt"><b><i><span style="color:blue">Results:</span></i></b> In saliva samples, the count of <i>C. Albicans</i> in the test group dropped significantly (p<0.05), while there were no significant differences between test and control groups in blood samples (p>0.05). Comparing the follow-up sessions, in the test groups, WBC and Neutrophil, and in the control groups, WBC count and hematocrit showed significant differences (p< 0.05).</span><br> <span style="line-height:13.7pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Based on the results, using probiotic products daily over a short-term period drops the count of oral <i>C. Albicans</i>. Therefore, Kefir probiotic products can be used as an additional treatment for chemotherapy patients.</span></span></span><br> &nbsp; Candida albicans, Kefir, Chemotherapy, Probiotic, Saliva 90 95 http://caspjim.com/browse.php?a_code=A-10-2034-2&slc_lang=en&sid=1 Dariush Moslemi moslemi_d@yahoo.com 100319475328460050513 100319475328460050513 No Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, Francertment of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France Sahar Latifi shr.latify@gmail.com 100319475328460050514 100319475328460050514 No Department of Oral and Maxillofacial Radiology Mohammad Mehdizadeh dr.rmohammad@yahoo.com 100319475328460050515 100319475328460050515 Yes Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Qom University of Medical Sciences, Qom, Iran