en Reumatology Reumatology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Pyoderma gangrenosum (PG) can be related to a range of systemic and hematologic diseases. The relationship between systemic lupus erythematosus (SLE) and PG has rarely been discussed.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case Presentation:</span></i></b> In this case study, we report on an SLE patient who presented with PG. The patient is a 53-year-old woman with the chief complaint of developing painful erythematous pustules on her right flank 3 days after hysterectomy surgery. In the span of 3 months, the patient was treated with antibiotics and intra-lesional corticosteroids with no improvement. Meanwhile, she developed symptoms such as polyarthralgia, pleural effusion, hemolytic anemia, and thrombocytopenia, while anti-dsDNA came out positive.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Result:</span></i></b> Based on pathology results in combination with clinical and para-clinical findings according to the SLICC criteria for SLE 2012, our patient was diagnosed as an active case of SLE presenting with PG. We also searched for and gathered the latest articles on this issue (from 2017 until 2022) to present the most updated review study on the topic in this article.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b><b> </b>Considering the abundance of PG and SLE concomitance reported cases (more than 30), it might be time to pay more attention to SLE as the underlying cause of PG and keep in mind that any unhealing ulcer in patients with connective tissue disorders should be evaluated for PG. Considering the various treatment options for PG, it is essential that the treatment of choice should cover symptoms of both PG and the underlying disease.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; pyoderma gangrenosum, lupus erythematous, lupus panniculitis, dermatology, rheumatology 577 583 http://caspjim.com/browse.php?a_code=A-10-2877-2&slc_lang=en&sid=1 Shahrzad Rahmani shz_rahmani@yahoo.com 100319475328460053425 100319475328460053425 No Department of Rheumatology, Firoozgar Clinical Research Development Center (FCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran Azadeh Goodarzi goodarzi.a@iums.ac.ir 100319475328460053426 100319475328460053426 No Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran Amirhossein Akbarzadehpasha amirhosseinap73@gmail.com 100319475328460053427 100319475328460053427 No Department of Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran Homa Abri abrihoma@yahoo.com 100319475328460053428 100319475328460053428 No Department of Rheumatology, Firoozgar Clinical Research Development Center (FCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran Amir Mohamad Sadeghian ams.med76@gmail.com 100319475328460053429 100319475328460053429 No Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran Elham Behrangi elham.behrangi@gmail.com 100319475328460053430 100319475328460053430 No Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran Azadeh Laali azadehlaali@yahoo.com 100319475328460053431 100319475328460053431 No Department of Rheumatology, Firoozgar Clinical Research Development Center (FCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran Nasrin Shayanfar nasrin.shayanfar@gmail.com 100319475328460053432 100319475328460053432 No Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran Zahra Lotfi zahra_lotfi90@yahoo.com 100319475328460053433 100319475328460053433 Yes Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran