en Oncology Oncology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Rapid economic progress and cultural-social changes have led to lifestyle changes and increased risk of breast cancer all around the world, including Iran. This study aims to investigate the 30-year incremental pattern of breast cancer in patients of Shahid Rajaei Radiation Therapy Center in Babolsar, North of Iran<span dir="RTL" lang="FA">.‌‌</span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> In this cross-sectional study, the data were retrospectively extracted from the physical and electronic files of patients diagnosed with breast cancer from 1992 to 2021 every 5 year by census method, during the study, overall, 1326 patients&#39; information out of 6199 patients was analyzed using SPSSV.22 software at the level of p-value &le; 0.05<b><span dir="RTL" lang="FA">.</span></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> The average age of patients was 49.84 &plusmn; 11.26 years, which has been increasing over the years of study. (99.13%) 6143 patients were women, the mean and standard deviation of their BMI was 29.63 &plusmn; 6.00, the number of patients with stage 1 is increasing, and patients with stage 3 is decreasing. (65.70%) 871 people went through Radical Mastectomy (MRM), (19.68%) 261 people experienced metastasis. There was a statistically significant relation between the type of surgery, stage of cancer, metastasis, and local recurrence within the years of study (p<0.001).<span lang="FA" dir="RTL" style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Breast cancer and the age of getting it have increased in recent years. However, advanced stages as well as metastasis and local recurrence have decreased during the investigated years. Therefore, it is recommended to continuously warn women about the risk factors and develop suitable disease screening programs and implement them effectively.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; Breast cancer, Risk factor, Prevention, Metastasis 720 727 http://caspjim.com/browse.php?a_code=A-10-1864-4&slc_lang=en&sid=1 Mahboobeh Asgharian mahbube.asgharian@gmail.com 100319475328460044948 0009-0000-6325-9173 No Student Research Committee, Babol University of Medical Sciences , Babol, Iran Dariush Moslemi moslemi_d@yahoo.com 100319475328460044949 100319475328460044949 No Department of Radiation Oncology, Babol University of Medical Sciences, Babol, Iran Mohammad Ali Jahani Drmajahani@yahoo.com 100319475328460044950 100319475328460044950 Yes Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I R Iran Ali Bijani alibijani@yahoo.com 100319475328460044951 100319475328460044951 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I R Iran Hossein_Ali Nikbakht ep.nikbakht@gmail.com 100319475328460044952 100319475328460044952 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I R Iran Hakimeh Mehdizadeh h.mhdizadeh@yahoo.com 100319475328460044953 0009-0006-4822-6764 No Babol University of Medical Sciences, Babol, Iran