en Genetics Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Allelic variants of genes encoding enzymes of the esterase system (<i>CES1</i>) and P-glycoprotein (<i>ABCB1</i>) can change the metabolism and pharmacokinetics of dabigatran. Therefore, they act as determining factors in the development of side effects, especially bleeding. We analyzed the genotype&ndash;phenotype relationship of <i>ABCB1</i> (rs1045642, rs4148738, rs2032582, and rs1128503) and <i>CES1</i> (rs8192935, rs71647871, and rs2244613) polymorphisms in patients with atrial fibrillation who had been treated with dabigatran.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> A total of 150 patients were recruited for this study. TaqMan technology was used for SNP genotyping.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Patients with the rs2244613 GG genotype had a lower concentration (55.27 &plusmn; 34.22 ng/ml) compared to those with the TT genotype (63.33 &plusmn; 52.25 ng/ml) (additive model, P = 0.000). Individuals with the rs8192935 AA genotype had a lower concentration (52.72 &plusmn; 30.45 ng/ml) compared to those with the GG genotype (79.78 &plusmn; 57 ng/ml) (additive model, P = 0.001). The APTT values among the different genotypes of the <i>ABCB1</i> SNPs, rs4148738 and rs1045642, were significantly different (P = 0.035 and P = 0.024, respectively).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Our research demonstrates that the <i>CES1</i> polymorphisms, rs8192935 and rs2244613, are associated with the pharmacodynamics and pharmacokinetics of dabigatran in the Kazakh subpopulation.</span></span></span><br> &nbsp; CES1, ABCB1, genetic polymorphisms, dabigatran, pharmacogenetics, atrial fibrillation 499 508 http://caspjim.com/browse.php?a_code=A-10-3173-1&slc_lang=en&sid=1 Ayan Abdrakhmanov project21fp@gmail.com 100319475328460049029 100319475328460049029 Yes Department of Arrhythmology, National Research Cardiac Surgery Center, Turan 38, Astana, Kazakhstan Elena Zholdybayeva lenazhol@gmail.com 100319475328460049030 100319475328460049030 No National Center for Biotechnology, 13/5, Kurgalzhynskoye road, Astana, Kazakhstan Aizhana Shaimerdinova ai12-10@mail.ru 100319475328460049031 100319475328460049031 No Medical University Astana, Beibitshilik St 49/A, Astana, Kazakhstan Gulmira Kulmambetova kulmambetova@biocentr.kz 100319475328460049032 100319475328460049032 No National Center for Biotechnology, 13/5, Kurgalzhynskoye road, Astana, Kazakhstan Svetlana Abildinova sabildinova@list.ru 100319475328460049033 100319475328460049033 No Department of Arrhythmology, National Research Cardiac Surgery Center, Turan 38, Astana, Kazakhstan Rustam Albayev albaev78@bk.ru 100319475328460049034 100319475328460049034 No Hospital of the Medical Center of the Office of the President, E 495, Astana, Kazakhstan Gulnara Tuyakova tuyakova_g@inbox.ru 100319475328460049035 100319475328460049035 No Department of Arrhythmology, National Research Cardiac Surgery Center, Turan 38, Astana, Kazakhstan Elena Rib tarlan186@mail.ru 100319475328460049036 100319475328460049036 No Medical University Astana, Beibitshilik St 49/A, Astana, Kazakhstan Zhanasyl Suleimen zhanasyls@gmail.com 100319475328460049037 100319475328460049037 No Department of Arrhythmology, National Research Cardiac Surgery Center, Turan 38, Astana, Kazakhstan Zhanar Abdrakhmanova zhanna-ayan74@mail.ru 100319475328460049038 100319475328460049038 No Medical University Astana, Beibitshilik St 49/A, Astana, Kazakhstan Makhabbat Bekbossynova astanamaha@gmail.com 100319475328460049039 100319475328460049039 No Department of Arrhythmology, National Research Cardiac Surgery Center, Turan 38, Astana, Kazakhstan