en Hematology Hematology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> NUP98 gene fusions in acute myeloid leukemia (AML) have recently attracted much interest. Despite substantial research illuminating the roles of NUP98 fusions in the course of AML, their impacts on the outcome of patients with AML should be explored in more detail. As a result, this meta-analysis was designed to provide further light on the prognostic implications of NUP98 fusions in AML. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods</span></i></b><i><span style="color:blue">:</span></i> We completed an extensive search in PubMed, Scopus, and Web of Science to identify papers evaluating the prognostic effects of NUP98 rearrangements in patients with AML until August 22, 2022. In total, 15 publications with 6142 participants fulfilled the requirements for the current meta-analysis. All the qualified studies were examined for information regarding HRs and 95% confidence interval (95%CI) for overall survival (OS) and event-free survival (EFS). In addition, we utilized Comprehensive Meta-analysis software version 2 (CMA2) for calculating pooled HRs and 95% CI.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results</span></i></b><i><span style="color:blue">:</span></i> Our analyses for NUP98-NSD1 indicated that this fusion could significantly impact the outcome of patients with AML (pooled HR: 2.84; 95% CI: 2.49&ndash;3.24, <i>P</i>=0.000). Additionally, we observed a strong correlation between NUP98-KDM5A rearrangement and poor prognosis in AML (pooled HR: 2.65; 95% CI: 2.5-2.81; P=0.000). A subgroup analysis also showed that the NUP98-NSD1 and FLT3-ITD together confer a poor prognostic effect (pooled HR: 2.60, 95% CI: 1.61-4.18; P=0.000).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusions:</span></i></b> NUP98 fusions could significantly impact the outcome of patients with AML. The use of these fusions as prognostic indicators in AML seems rational.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Acute myeloid leukemia, prognosis, Nucleoporin98, NUP 98 579 588 http://caspjim.com/browse.php?a_code=A-10-2544-4&slc_lang=en&sid=1 Maryam Sheikhi SheikhiM2@mums.ac.ir 100319475328460049889 100319475328460049889 No Cancer Molecular Pathology Research Center, Mashhad University of Medical sciences, Mashhad, Iran. Payam Siyadat payam.siyadat19899@gmail.com 100319475328460049890 100319475328460049890 No Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran Mehrdad Rostami m.rostami9675@gmail.com 100319475328460049891 100319475328460049891 No Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Hadi Sadeghian sadeghianmh@mums.ac.ir 100319475328460049892 100319475328460049892 No Cancer Molecular Pathology Research Center, Mashhad University of Medical sciences, Mashhad, Iran Elnaz Zahiri Zahirie3@mums.ac.ir 100319475328460049893 100319475328460049893 No Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Ghorbani m.ghorbani@sbmu.ac.ir 100319475328460049894 100319475328460049894 No PHD student of Hematology and Transfusion Science, Pathology Department, Gonabad University of Medical Sciences, Gonabad, Iran Hossein Ayatollahi ayatollahih@mums.ac.ir 100319475328460049895 100319475328460049895 No Cancer Molecular Pathology Research Center, Mashhad University of Medical sciences, Mashhad, Iran. Amirali Ayatollahi aytamirali@gmail.com 100319475328460049896 100319475328460049896 No Cancer Molecular Pathology Research Center, Mashhad University of Medical sciences, Mashhad, Iran. Reza Hemmatan Attarbashi Reza.hematan@gmail.com 100319475328460049897 100319475328460049897 No Cancer Molecular Pathology Research Center, Mashhad University of Medical sciences, Mashhad, Iran Zahra Khoshnegah zkhoshnegah@gmail.com 100319475328460049898 100319475328460049898 Yes Department of Hematology and Blood Banking, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.