en Microbiology Microbiology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:13.5pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Biofilms are organized communities of microorganisms encased in a self-produced matrix that adheres to surfaces and can have both beneficial and detrimental effects in various environments. These biofilms have been linked to severe infections in humans. We investigated the association between antibiotic resistance and biofilm formation in methicillin-resistant <i>Staphylococcus epidermidis</i> (MRSE) isolates. </span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Methods:</span></i></b> A comprehensive search was conducted through data medical data bases using a combination of mesh terms. The data were analyzed using STATA meta-analysis software, and a random effects model was employed to determine the pooled prevalence with a 95% confidence interval (CI).</span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Results:</span></i></b> Our findings revealed that the prevalence of MRSA was 61.75% (95% CI: 35.6-99.1). The cumulative rate of biofilm formation in MRSE strains was reported to be 83.4% (95% CI: 47.8-99.4). Among the biofilm-related genes, the <i>SdrG</i> gene exhibited the highest frequency (98%), followed by the <i>atlG<span style="color:red"> </span></i>gene with a frequency of 84%.</span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Out of the seven, three documented a positive association. Given the propensity of MRSE strains to form biofilms, it is crucial to implement preventive measures against infections caused by these strains.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; biofilm, antibiotic resistance, correlation, methicillin-resistant Staphylococcus epidermidis 225 232 http://caspjim.com/browse.php?a_code=A-10-3186-1&slc_lang=en&sid=1 Parisa Behshood Parisa_behshood@yahoo.com 100319475328460052187 100319475328460052187 No Department of Biology, Islamic Azad University, Shahrekord Unit, Shahrekord, Iran Elaheh Tajbakhsh elahe.tajbakhsh64@yahoo.com 100319475328460052188 100319475328460052188 Yes Department of Biology, Islamic Azad University, Shahrekord Unit, Shahrekord, Iran