en Health Health Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Osteoporosis is the most common metabolic bone disease that begins with a decrease in bone mass and deterioration in the micro-architecture of the bone tissue, making the bones thinner and susceptible to fragility. A comprehensive estimation of the prevalence of osteoporosis in provinces of Iran seems to be necessary.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span style="color:black">This study was a descriptive-analytical study. The study population included 518 people aged 30-65 years including 297 males and 221 females to measure their bone density. The data collection method was through BMD measurement using Dual-Energy X-ray Absorptiometry (DXA) method. All obtained data stored in the SPSS-16 database and statistically analyzed. The data analyzed using analytical, statistical methods. The significance level of the test was considered to be P&le;0.05.</span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span style="color:black">In the present study, according to BMI status, 45.2% of the patients were obese, 38.2% were overweight. Despite the general belief that increasing in weight can be associated with an increase in bone mass, the present research revealed that nearly 35.9% of the research population, suffered obesity and osteoporosis at the same time. Metargression analysis of data from different studies have illustrated that changing in frequency of osteoporosis as an oriented change in prevalence of osteoporosis from west to east and south to north (P&le;0.05)</span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Iran society is under concern to more osteoporosis in the coming years at young and old ages which doubled with severe decline in growth rate of population from 3.7% to 0.63% in 2022. This can increase older people ratio over 30% in 2050<span dir="RTL" lang="FA">.</span><span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; Osteoporosis, Osteopenia, Iran, Obesity, D3 level, Mazandaran province 629 635 http://caspjim.com/browse.php?a_code=A-10-3193-1&slc_lang=en&sid=1 Majid Malekzadeh Shafaroudi malek1344@gmail.com 100319475328460049943 100319475328460049943 Yes Immunogenetic Research Center (IRC), Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Nourollah Rezaei nourrezaei@gmail.com 100319475328460049944 100319475328460049944 No Department of Anatomy and Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Behrooz Mohammadnegad Behroozm_2012@yahoo.com 100319475328460049945 100319475328460049945 No Department of Anatomy and Cell Biology, Sari Faculty Medicine, Mazandaran University of Medical Sciences, Mazandaran, Sari- Iran Gholamali Usefi Usefi547@gmail.com 100319475328460049946 100319475328460049946 No Densitometry specialist, Vali e Asr Hospital, Ghaemshahr- Iran Ali Malekzadeh Shafaroudi amshafaroudi@gmail.com 100319475328460049947 100319475328460049947 No Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran