en Nephrology Nephrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">: </span></i>Dialysis cuffed catheter dysfunction results in inadequate dialysis, increased sepsis risk,&nbsp;and a shortened&nbsp;catheter life. It may be possible to prolong catheter function by identifying the causes of cuffed catheter dysfunction.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods: </span></i></b>This study was a cross-sectional descriptive study conducted in 2021-2022 on hemodialysis patients with jugular cuff catheters. The catheterizations were performed using the Seldinger technique and were confirmed by fluoroscopy. A 12-month follow-up was conducted with respect to the performance of the cuffed catheter.&nbsp;</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results: </span></i></b>A total of 123 patients underwent hemodialysis over 2 years via a cuffed catheter. Catheters were most commonly inserted into the right internal jugular vein, with lengths of 19 cm (tip to cuff). The rate of dysfunction of cuffed catheters was 27.6%. Catheter-related thrombosis was the most common cause in 10 cases (29.4%), followed by catheter tip fibrin sheath in 8 cases (23.5%) and catheter tip malposition in 8 cases (23.5%). Furthermore, 18 patients (52.94%) of cuffed catheter dysfunction occurred within 3 months of catheter placement, based on our study. The dysfunction of cuffed catheters on the left side 23 (67.64%) is more prevalent than the right side 11 (32.35%) (P=0.043); the malposition of catheter tips is more prevalent on the left side (P=0.023).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">: </span></i>Most commonly, cuffed catheter dysfunction is caused by thrombosis, fibrin sheath formation, and catheter tip malposition. Cuffed catheter failure can be reduced by carefully monitoring the catheter&#39;s path and tip position, searching for fibrin sheaths when investigating cuffed catheter failure, and preventing thrombotic events.</span></span></span><br> &nbsp; Renal Dialysis, Vascular Catheters, Thrombosis, Fibrin Adhesive 439 443 http://caspjim.com/browse.php?a_code=A-10-248-3&slc_lang=en&sid=1 Pouya Tayebi p.tayebi@yahoo.com 100319475328460048924 100319475328460048924 Yes Department of Vascular and Endovascular Surgery, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. Kosar Hasanzadeh k.h363@rocketmail.com 100319475328460048925 0009-0000-9408-5217 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Masoumeh Asgharpour masi9932002@yahoo.com 100319475328460048926 100319475328460048926 No Department of Nephrology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. Ali Bijani alibijani@yahoo.com 100319475328460048927 100319475328460048927 No Social Determinant of Health Research Center, Babol University of Medical Sciences, Babol, Iran Naghmeh Ziaie ziaiexn@yahoo.com 100319475328460048928 100319475328460048928 No Department of Cardiology, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.