en Internal Internal Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:15.0pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> To date, the clinical implications of the long-lasting non-alcoholic fatty liver disease (NAFLD) such as the left ventricular diastolic dysfunction (LVDD) in the course of type 2 diabetes mellitus (T2DM) are yet to be determined. The main aim of this study was to investigate the correlation between NAFLD and early LVDD progression along with demographic characteristics. </span><br> <span style="line-height:15.0pt"><b><i><span style="color:blue">Methods:</span></i></b> This cross-sectional study was performed on ninety consecutive diabetic outpatients referred to the endocrinology clinic. Demographic data were collected using a designed checklist. Ultrasound imaging was performed to assess the fatty liver condition. To assess LV diastolic function, echocardiography was performed, using a trans-thoracic tissue Doppler echocardiography. </span><br> <span style="line-height:15.0pt"><b><i><span style="color:blue">Results</span></i></b>: <span lang="EN">The results showed that the majority of participants were females (61.1%). The fasting blood glucose (FBG,</span> <span lang="EN">mg/dl) level was 174.65 &plusmn;51.1. Also, the mean body mass index (BMI) was 28.92&plusmn;4.19, which was significantly associated with NAFLD. It has been also estimated that 76.7% and 81.1% of diabetic patients had NAFLD and simultaneous LVDD, respectively. However, the statistical results did not show a significant association between non-progressive NAFLD and LVDD (p<0.05)</span><span dir="RTL" lang="AR-SA">.</span><b><span style="font-size:10.0pt"></span></b></span><br> <span style="line-height:15.0pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> There was no correlation between NAFLD and LVDD progression. However,<span lang="EN"> timely evaluation of LVDD in T2DM outpatients with NAFLD can strongly help to prevent possible cardiomyopathy in high-risk populations.</span> <span lang="EN" style="font-size:10.0pt"></span></span></span></span><br> <br> <span style="font-size:11pt"><span style="line-height:115%"><span calibri="" style="font-family:"><span style="font-size:13.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span> Early Diagnosis, Ventricular Dysfunction, Fatty Liver, Type 2 Diabetes Mellitus, Risk factors 47 57 http://caspjim.com/browse.php?a_code=A-10-3250-1&slc_lang=en&sid=1 Maryam Faramarzpour faramarzpour.m94@gmail.com 100319475328460050478 100319475328460050478 No Department of Cardiology, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran Mohammadreza Mohammad Hosseiniazar mohammadazar@gmail.com 100319475328460050479 100319475328460050479 No Department of Internal Medicine, School of Medicine, Taleghani Hospital, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran Laya Hooshmand Gharabagh Laya.hooshmand58@gmail.com 100319475328460050480 100319475328460050480 Yes Department of Internal Medicine, School of Medicine, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran