en Pulmonology Pulmonology Letter to Editor Letter to Editor <p><span style="font-size:12pt"><span style="font-size:10.0pt">The use of morphine should be carefully considered and administered under the supervision of medical professionals due to the risks associated with opioids, including respiratory depression and the potential for addiction or dependency. Additionally, it could be potentially harmful in late stages of severe COVID-19, especially in the presence of septic shock. Close monitoring and dosage adjustments are necessary to ensure patient safety and optimal pain management.</span></span><br> &nbsp;</p> COVID-19, Morphine,Acetaminophen 381 383 http://caspjim.com/browse.php?a_code=A-10-3270-1&slc_lang=en&sid=1 Seyed Mohammadreza Hashemian iran.criticalcare@yahoo.com 100319475328460052327 100319475328460052327 Yes 1. Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ameneh Jafari amenehjafari@gmail.com 100319475328460052328 100319475328460052328 No 1. Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran Parviz Amri Maleh pamrimaleh@gmail.com 100319475328460052329 100319475328460052329 No Department of Anesthesiology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran