en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:13.0pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Patients with moderate to severe chronic heart failure (CHF) are at high risk for cardiac mortality. Cardiac resynchronization therapy <span style="color:black">with defibrillators (CRT-D) as a potentiall</span>y beneficial option can improve the clinical outcomes of such patients.</span><br> <span style="line-height:13.0pt"><b><i><span style="color:blue">Methods:</span></i></b> We conducted a single-arm clinical trial in which 48 patients with moderate to severe CHF were investigated regarding the beneficial outcome of CRT-D insertion. All participants were evaluated regarding different functional and echocardiographic factors including New York Heart Association (NYHA) functional class (FC), left ventricular ejection fraction (LVEF), mitral regurgitation (MR) as well as left ventricular end-systolic (LVESD) and end-diastolic (LVEDD) before and one month after the procedure. Furthermore, we investigated the influence of different variables including age, gender, and comorbidities on the aforementioned clinical and echocardiographic factors.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:13.0pt"><b><i><span style="color:blue">Results:</span></i></b> <span style="color:black">Of the 48 CHF patients included in our study, 24 (50%) were males and 24 (50%) were females. The mean &plusmn; standard deviation (range) of the participants&rsquo; age was 55.6&plusmn;6.5 (40-69) years. CRT-D insertion significantly improved all functional and echocardiographic factors in CHF patients. The participants had a mean&plusmn;standard deviation (range) LVEF of 22.1&plusmn;5.8% (10-30%) before CRT-D insertion. A follow-up echocardiography performed one month after the implantation of CRT-D demonstrated a significant increase in LVEF to 27.1&plusmn;5.5% (15-38%) (<i>p</i><0.001). Additionally, echocardiography conducted one month after CRT-D insertion showed a reduction of LVESD from 6.8&plusmn;0.5 cm (5.8-7.4 cm) to 6.2&plusmn;0.5 cm (5.3-7.3 cm) (<i>p</i><0.001).</span><span style="color:red"></span></span><br> <span style="line-height:13.0pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> There is prominent evidence for CRT-D insertion in reducing symptoms of heart failure as well as improving different echocardiography variables in patients with moderate to severe CHF.</span></span></span><br> &nbsp; Cardiac Resynchronization Therapy, Defibrillators, Implantable 233 238 http://caspjim.com/browse.php?a_code=A-10-3276-1&slc_lang=en&sid=1 Hossein Salehi Omran hosseinsalehiomran@gmail.com 100319475328460054876 100319475328460054876 No Department of Cardiology, Ayatollah Rouhani Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran Amir Balouchzadeh amirbalouchzadeh9@gmail.com 100319475328460054877 100319475328460054877 No Neyshabur University of Medical Sciences, Neyshabur, Iran Sina Dolatshahi sinahbk32@gmail.com 100319475328460054878 100319475328460054878 No School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Saeed Abrotan Abrotan@yahoo.com 100319475328460054879 100319475328460054879 No Department of Cardiology, Ayatollah Rouhani Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran Mohammad Taghi Salehi Omran tomran40@yahoo.com 100319475328460054880 100319475328460054880 No Department of Cardiology, Ayatollah Rouhani Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran Mehrdad Saravi mehrdadsaravi@gmail.com 100319475328460054881 100319475328460054881 No Department of Cardiology, Ayatollah Rouhani Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran Sara Aboutalebazadeh sara.tzict74@gmail.com 100319475328460054882 0009-0007-1066-6040 No Mazandaran University, Babolsar, Iran Mohammad Taghi Hedayati Goudarzi Drmohammad.Hedayati@yahoo.com 100319475328460054883 100319475328460054883 Yes Cardiology Department, Rohani Hospital, School of Medicine, Babol University of Medical Sciences, Babol, Iran