en Pulmonology Pulmonology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Studies have shown that carotid intima-media thickness (CIMT) is an indicator of cardiovascular events and mortality and its increase has correlation with severe airflow obstruction in patients with COPD. The aim of this study was to investigate the association between pulmonary function and CIMT in COPD patients. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This study was performed on two groups of patients with and without COPD (cases & controls) who were referred to pulmonary clinics. Demographic, clinical, and laboratory tests were recorded in questionnaire. Spirometry was performed in cases and FVC, FEV1, and FEV1/FVC were measured. CIMT was determined via ultrasound. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Our results indicated that right carotid IMT was 0.51&plusmn;0.112 mm and 0.65&plusmn;0.131 mm in the control and case groups, respectively (p< 0.001). Left CIMT was 0.48&plusmn;0.089 mm and 0.68&plusmn;0.113 mm in the control and case groups, respectively (p< 0.001). FEV1 and FEV1/FVC had an inverse and significant correlation with IMT of the carotid (both right and left carotid).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The results indicated an inverse association between carotid IMT and lung function test in COPD patients.</span></span></span><br> &nbsp; Pulmonary Disease, Chronic Obstructive, Carotid Intima-Media Thickness , Forced Expiratory Volume 487 492 http://caspjim.com/browse.php?a_code=A-10-2936-2&slc_lang=en&sid=1 Shahabaddin Sorouri shahab_s59@yahoo.com 100319475328460053311 100319475328460053311 Yes Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Naseri Maryamnaseri63@yahoo.com 100319475328460053312 100319475328460053312 No Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran Sepideh Hejazi HejaziS@mums.ac.ir 100319475328460053313 100319475328460053313 No Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran