en Oncology Oncology Original Article Original Article <p><span style="font-family:Times New Roman"><span style="font-size:14px"><strong><em><span style="color:blue">Background</span></em></strong><em><span style="color:blue">:</span></em> Multiple myeloma (MM) is characterized by reduced circulating adiponectin levels, a condition associated with various diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer, and plasma dyscrasias. Curcumin has been shown to inhibit adipogenesis and elevate serum adiponectin levels. Notably, limited studies investigating the relationship between adiponectin levels and curcumin supplementation in myeloma patients. This study is to evaluate the efficacy curcumin supplements on increasing the levels of adiponectin in myeloma patients<br> <strong><em><span style="color:blue">Methods:</span></em></strong> Patients with myeloma were randomly to melphalan, prednisone, curcumin (MPC) (n=17) and melphalan with prednisone (MP) (n=16) groups. The MPC group was treated by melphalan 4 mg/m² and prednisone 40 mg/m² for 7 days (MP), and curcumin 8 grams daily for 28 days. The MP group received MP and placebo. Subjects were followed-up every 28 days and a total of four treatment cycles. Hemoglobin, albumin, white blood cell (WBC), platelets, urea, creatinine, calcium, protein M, and adiponectin evaluated before and after treatment. Mann Whitney test or the Independent T-test were used to analysis<br> <strong><em><span style="color:blue">Results:</span></em></strong> Total subject (24 subjects) completed the treatment. Serum adiponectin levels after four treatment cycles in the MPC group were higher than in the MP group [(mean, 12227.1<span style="color:black">&plusmn;</span>5748.3) vs (11365.4<span style="color:black">&plusmn;</span>9175.5), P = 0.78]<br> <strong><em><span style="color:blue">Conclusion</span></em></strong><em><span style="color:blue">:</span></em> Supplementing MP regimen with 8000 mg curcumin daily for 28 days increases the serum adiponectin level after four treatment cycles in myeloma patients. This research found that myeloma patients may benefit by taking curcumin supplementation.</span></span><br> &nbsp;</p> Multiple myeloma, curcumin, adiponectin 320 327 http://caspjim.com/browse.php?a_code=A-10-3310-1&slc_lang=en&sid=1 Damai Santosa santosaivha@fk.undip.ac.id 100319475328460052274 100319475328460052274 Yes Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Damar Mashkun Rizqi dokterdamar@gmail.com 100319475328460052275 100319475328460052275 No Department of Internal Medicine, RSUD Hj. Anna Lasmanah Banjarnegara, Jawa Tengah, Indonesia Eko Adhi Pangarsa pangarsa90@gmail.com 100319475328460052276 100319475328460052276 No Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Budi Setiawan boedhi_73@gmail.com 100319475328460052277 100319475328460052277 No Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Suyono Suyono ilmiahapbmt2023@gmail.com 100319475328460052278 100319475328460052278 No Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Mika Lumban Tobing annualmeeting2023.apbmt@gmail.com 100319475328460052279 100319475328460052279 No Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Suhartono Suhartono Suhartono.damas62@gmail.com 100319475328460052280 100319475328460052280 No Department of Environmental Health, Faculty of Public Health, Diponegoro University, Jawa Tengah, Indonesia Soeharyo Hadisaputro prof_haryo@yahoo.co.id 100319475328460052281 100319475328460052281 No Division of Topical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia Ignatius Riwanto irwanto@gmail.com 100319475328460052282 100319475328460052282 No Department of Surgery, Faculty of Medicine, Diponegoro University, Semarang, Indonesia Aru Wisaksono Sudoyo arusudoyo@gmail.com 100319475328460052283 100319475328460052283 No Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. Catharina Suharti hemasemarang@gmail.com 100319475328460052284 100319475328460052284 No Division of Hematology-Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Jawa Tengah, Indonesia