en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Poor adherence to treatment is an obstacle to reach the target level of lipids. The purpose of the study was to investigate the impact of patient-oriented intervention with primary focus on patients&rsquo; adherence to lipid-lowering therapy on low-density lipoprotein cholesterol (LDL-C) in patients with dyslipidemia and receiving statins for primary prevention of cardiovascular diseases (CVD).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> A prospective, open-label, randomized, multicenter study in parallel groups. Data was collected from 11 study sites. 2,912 patients were recruited between June 2018 and August 2019. Test Intervention: extended consultation on drug compliance, patient-oriented printed materials about CVD prevention, SMS- and phone reminders. The primary endpoint was LDL-C. Chi-square test or Fisher&rsquo;s exact test was used for qualitative variables. Paired Wilcoxon test was used to compare the variables between patient visits. The odds ratio (OR) at 95% confidence interval (CI) was defined as the ratio of the chance of fulfilling the criterion in the group or subgroup (subpopulation).<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> At 12 month, the number of patients achieving target levels of LDL-C, total cholesterol (TC) and blood pressure (BP) was significantly higher in the intervention group vs control (LDL-C: 80% vs. 70%, OR: 1.68, 95% CI: 1.40 to 2.01, p<0.001; TC: 80% vs. 67%, OR: 1.92, 95% CI: 1.60 to 2.29, p<0.001; BP: 85% vs 79%, OR: 1.49, 95% CI:1.22 to 1.83, p=0.0001).<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Proposed patient-oriented intervention helps to achieve the target level of LDL-C, TC and supports better control of BP in patients receiving statins for primary prevention of CVD.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; Cholesterol, drug compliance, dyslipidemia, patient-oriented preventive intervention, primary cardiovascular prevention, statins 458 467 http://caspjim.com/browse.php?a_code=A-10-3328-1&slc_lang=en&sid=1 Elena Bochkareva ebochkareva@gnicpm.ru 100319475328460053296 100319475328460053296 No National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia Sergey Boytsov prof.boytsov@gmail.com 100319475328460053297 100319475328460053297 No National Medical Research Center of Cardiology, Moscow, Russia Oxana Drapkina drapkina@bk.ru 100319475328460053298 100319475328460053298 No National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia Oleg Melikhov melikhov.oleg@gmail.com 100319475328460053299 100319475328460053299 No Institute of Clinical Research, Moscow, Russia Ekaterina Butina ebutina@gnicpm.ru 100319475328460053300 100319475328460053300 No National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia Irina Kim ivkimivkim@gmail.com 100319475328460053301 100319475328460053301 Yes National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia