en Internal Internal Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:13.9pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Anemia in pregnancy is associated with psychiatric symptoms and poor psychiatric symptoms, this study investigates the 6-month trends of anxiety and birth outcomes. Considering the controversies surrounding the impact of anemia on psychiatric symptoms, this study investigates the 6-month trends of anxiety and depression in anemic pregnant women with threatened abortion (TA).<span lang="FA" dir="RTL" style="font-size:10.0pt"></span></span><br> <span style="line-height:13.9pt"><b><i><span style="color:blue">Methods:</span></i></b> A case-control retrospective cohort study conducted among 282 participants who enrolled in a registry of pregnant women with TA in Babol city from December 2022 to October 2023. Fifty individuals with anemia (hemoglobin < 11 g/dL) who were matched with 50 without anemia based on age, pregnancies, education, and gestational age, were included. The BSI-18 (Brief Symptom Inventory) was used to assess depression, anxiety, and psychological distress at the beginning, three and six-month follow-ups.</span><br> <span style="line-height:13.9pt"><b><i><span style="color:blue">Results:</span></i></b> The prevalence of anemia among women diagnosed with TA was found to be 17.7%. At the beginning, compared to normal individuals, anemic women had higher rates of depression (32% vs. 14%), anxiety (34% vs. 22%), and psychological distress (66% vs. 48%). Moreover, at 3- and 6-month follow-ups, the frequency of psychiatric symptoms in anemic women was significantly higher. The Generalized Estimating Equations model showed that although both groups had a decreasing trend of frequency anemic women experience a slower rate of decrease in psychiatric symptoms compared to non-anemic women.</span><br> <span style="line-height:13.9pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Anemia in women with TA is associated with high rates of depression, anxiety, and psychological distress, as well as a slow recovery rate.</span></span></span> Anemia, Threatened abortion, Depression, Anxiety, Psychological distress 158 164 http://caspjim.com/browse.php?a_code=A-10-112-2&slc_lang=en&sid=1 Seyyedeh Mahboobeh Mirtabar seyedehm.mirtabar@gmail.com 100319475328460050595 100319475328460050595 No Student Research Committee, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Shahnaz Barat dr.shahnazbarat@gmail.com 100319475328460050596 100319475328460050596 No Infertility and Reproductive Health Research Center, Health Research Institute, Babol, Iran Farzan Kheirkhah drfarzankh@yahoo.com 100319475328460050597 100319475328460050597 No Social Determinants of Health Research Center, Health Research Institute, Babol, Iran Amrolah Mostafazadeh Amrolah65@yahoo.co 100319475328460050598 100319475328460050598 No Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Hoda Shirafkan hodashirafkan@gmail.com 100319475328460050599 100319475328460050599 No Social Determinants of Health Research Center, Health Research Institute, Babol, Iran Zeinab Pahlavan dr.z.pahlavan@gmail.com 100319475328460050600 100319475328460050600 No Infertility and Reproductive Health Research Center, Health Research Institute, Babol, Iran Mahbobeh Faramarzi mahbob330@yahoo.com 100319475328460050601 100319475328460050601 Yes Social Determinants of Health Research Center, Health Research Institute, Babol, Iran