en Surgery Surgery Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.5pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> The maturation of the arteriovenous fistula (AVF) is necessary for successful hemodialysis treatment. However, the role of antihypertensive drugs in influencing AVF maturation remains uncertain. This study investigated the AVF maturation in patients with renal failure treated with antihypertensive medications.</span><br> <span style="line-height:14.5pt"><b><i><span style="color:blue">Methods:</span></i></b> A prospective cohort study was conducted on 73 patients who needed to be treated with hemodialysis through AVF. Demographic information, medication, underlying diseases, blood pressure changes, surgical information, and the time of AVF maturation were collected during the study. Descriptive statistics and survival analysis were employed to assess the outcomes.</span><br> <span style="line-height:14.5pt"><b><i><span style="color:blue">Results:</span></i></b> The mean age of patients was 53.96&plusmn;13.65 years, with 38 (52.1%) males and 35 (47.9%) females. The mean AVF maturation time was 104.87&plusmn;1.02 days, and the rate of AVF maturation was 87.7%. Among the comorbidities, the rate of AVF maturation in diabetic patients (78.4%) versus non-diabetic (97.2%) exhibited a notably diminished effect (P = 0.028). There was a significant association between mean intraoperative arterial blood pressure (123.45&plusmn;2.89 mmHg) and AVF maturation time (P = 0.033). Furthermore, there were not any significant differences in the use of antihypertensive medications on AVF maturation time or rates.</span><br> <span style="line-height:14.5pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Our study findings suggest that the administration of antihypertensive medications did not demonstrate a significant correlation with either the AVF maturation outcome or the time required for maturation.</span></span></span> Arteriovenous Fistula, Antihypertensive Agents, Renal Dialysis, Arteriovenous Fistula Maturation, Blood Pressure 500 506 http://caspjim.com/browse.php?a_code=A-10-248-4&slc_lang=en&sid=1 Fatemeh Mahmoudlou Fateme.mhloo197@gmail.com 100319475328460053550 100319475328460053550 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Pouya Tayebi p.tayebi@yahoo.com 100319475328460053551 100319475328460053551 Yes Department of Vascular and Endovascular Surgery, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Aliakbar Moghadamnia Moghadamnia@gmail.com 100319475328460053552 100319475328460053552 No Department of Pharmacology and Toxicology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Ali Bijani alibijani@yahoo.com 100319475328460053553 100319475328460053553 No Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran