en Gastroentrology Gastroentrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Early colorectal cancer (CRC) detection helps reduce the mortality rate. This study aimed to investigate colon lesions in individuals with positive and negative fecal immunochemical test (FIT) results among the (PERSIAN) Guilan cohort study (PGCS) population<b>.</b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This cross-sectional study was conducted on 1158 participants over 50 who were volunteers for the FIT stool test at the Endoscopy Department of Razi Hospital, Rasht, Iran, from 2021 to 2022. The FIT test was screened for all participants, and for 172 individuals (86 individuals from each group with positive and negative FIT results), a colonoscopy was performed to investigate the colon lesions. Demographic/clinical characteristics, FIT results, colonoscopy findings, and the Bristol Stool Chart were completed. All data were analyzed using SPSS Version 16, considering a significant level<0.05<b>.</b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Out of 1,158 participants, 86 had positive FIT results, and 172 (52.3%) were females. The colonoscopy results showed that 34.3% of the patients had colon lesions. Individuals with positive FIT exhibited a significantly higher prevalence of colon lesions (p<0.001). No statistically significant differences were observed between positive and negative FIT results, demographic and clinical characteristics, and the location of lesions in individuals with colon lesions (p>0.05). Moreover, there was a significant difference in pathological findings and the presence of adenomatous polyps regarding the FIT results (p<0.001).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The effectiveness of FIT in the initial stages of screening for early lesion detection is considerable, especially for individuals with upper age. </span></span></span><br> &nbsp; Colonic neoplasms, Colonoscopy, Colorectal neoplasms 451 457 http://caspjim.com/browse.php?a_code=A-10-2942-6&slc_lang=en&sid=1 Heydar Ali Balou Habalou98@gmail.com 100319475328460053287 100319475328460053287 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Farahnaz Joukar farajov@gmail.com 100319475328460053288 100319475328460053288 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Mahdi Orang Goorabzarmakhi orangmahdi17@gmail.com 100319475328460053289 0009-0009-4100-7624 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Milad Shahdkar dr.shahdkar@gmail.com 100319475328460053290 0009-0001-3270-6556 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Soheil Hassanipour Soheil.epid@gmail.com 100319475328460053291 100319475328460053291 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Saman Maroufizadeh Saman.maroufizadeh@gmail.com 100319475328460053292 100319475328460053292 No Department of Biostatistics, School of Health, Guilan University of Medical Sciences, Rasht, Iran Mehrnaz Asgharnezhad Asgharnezhad98@yahoo.com 100319475328460053293 100319475328460053293 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Paridokht Karimian paridokhtkarimian@yahoo.com 100319475328460053294 100319475328460053294 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Fariborz Mansour-Ghanaei fmansourghanaei@gmail.com 100319475328460053295 100319475328460053295 Yes Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran